Factors associated with diabetic nephropathy in subjects with proliferative retinopathy

Aim The purpose was to compare the phenotype of subjects with type 2 diabetes mellitus having both retinopathy and nephropathy with that of subjects having retinopathy but no nephropathy. Methods We recruited 196 subjects; 85 were normoalbuminuric (controls), whilst cases consisted of patients with...

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Bibliographic Details
Published in:International urology and nephrology 2012-02, Vol.44 (1), p.197-206
Main Authors: Magri, Caroline Jane, Calleja, Neville, Buhagiar, Gerald, Fava, Stephen, Vassallo, Josanne
Format: Article
Language:English
Subjects:
Aged
Albuminuria - etiology
Blood Pressure
Blood Sedimentation
C-Reactive Protein - metabolism
Circadian Rhythm
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - physiopathology
Diabetic Nephropathies - blood
Diabetic Nephropathies - complications
Diabetic Nephropathies - physiopathology
Diabetic Retinopathy - blood
Diabetic Retinopathy - complications
Diabetic Retinopathy - physiopathology
Diastole
Female
Glomerular Filtration Rate
Hemoglobins - metabolism
Humans
Insulin Resistance
Leukocyte Count
Male
Medicine
Medicine & Public Health
Middle Aged
Multivariate Analysis
Nephrology
Nephrology – Original Paper
Phenotype
Platelet Count
Pulse
Systole
Triglycerides - blood
Uric Acid - blood
Urology
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Summary:Aim The purpose was to compare the phenotype of subjects with type 2 diabetes mellitus having both retinopathy and nephropathy with that of subjects having retinopathy but no nephropathy. Methods We recruited 196 subjects; 85 were normoalbuminuric (controls), whilst cases consisted of patients with micro- ( n  = 66) or macroalbuminuria ( n  = 45). Both groups underwent 24-h blood pressure (BP) monitoring and were analysed regarding markers of the metabolic syndrome, inflammation (erythrocyte sedimentation rate [ESR] and high-sensitivity CRP [hsCRP]) and insulin resistance (HOMA-IR). Results Cases had significantly higher white cell count ( P  = 0.02), ESR ( P  
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-011-9958-1