Spindle cell oncocytoma of the adenohypophysis

Spindle cell oncocytoma of the adenohypophysis (SCO) is defined as spindle to epithelioid cells with oncocytic appearance presenting in the adenohypophysis. In contrast to pituitary adenomas, the SCO does not show immunoreactivity for neuroendocrine markers and pituitary hormones but co-expressed vi...

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Bibliographic Details
Published in:Brain tumor pathology 2011-10, Vol.28 (4), p.359-364
Main Authors: Romero-Rojas, Alfredo Ernesto, Melo-Uribe, Mario Alexander, Barajas-Solano, Paula Alejandra, Chinchilla-Olaya, Sandra Isabel, Escobar, Ligia Inés Restrepo, Hernandez-Walteros, Diana Marcela
Format: Article
Language:English
Subjects:
Adenoma, Oxyphilic - pathology
Adult
Antigens
Cancer Research
Case Report
Cloning
Female
Follicles
Growth factors
Growth hormones
Humans
Medicine
Medicine & Public Health
Microscopy
Mitochondria
Monoclonal antibodies
Neurology
Neurosurgery
Oncology
Pathology
Pituitary Gland, Anterior - pathology
Pituitary Neoplasms - pathology
Proteins
Smooth muscle
Stem cells
Thyroid gland
Tumors
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Summary:Spindle cell oncocytoma of the adenohypophysis (SCO) is defined as spindle to epithelioid cells with oncocytic appearance presenting in the adenohypophysis. In contrast to pituitary adenomas, the SCO does not show immunoreactivity for neuroendocrine markers and pituitary hormones but co-expressed vimentin, S-100 protein, epithelial membrane antigen (EMA), and antimitochondrial antibody MU213-UC clone 131-1. We describe an SCO in an adult, a 42-year-old woman whose magnetic resonance (MR) images documented an intrasellar lesion located in the hypophysis. Histopathological examination showed a tumor composed predominantly of spindle cells. Immunohistochemical studies showed positivity for vimentin, S10, EMA, and antimitochondrial antibody MU213-UC clone 131. Cytokeratin (CK) (AE1/AE3), glial fibrillary acidic protein (GFAP), chromogranin, synaptophysin, PGP9.5, CD57, desmin, D2-40, smooth muscle actin (SMA), Bcl-2, progesterone receptor, and CD34 were negative. Neuropeptides were negative. With electron microscopy, the neoplastic cells appear filled with mitochondria, well-formed desmosomes, but lacked secretory granules. SPO is a rare non-endocrine neoplasm of the adenohypophysis with benign biological behavior corresponding to WHO grade I.
ISSN:1433-7398
1861-387X
DOI:10.1007/s10014-011-0051-3