Two modes of immune suppression by Foxp3+ regulatory T cells under inflammatory or non-inflammatory conditions

Highlights ► Suppressive mechanisms mediated by CD4+ Foxp3+ regulatory T cells (Tregs) are reviewed. ► In physiological states, Tregs deprive co-stimuli from other T cells to suppress their activation. ► Under inflammatory conditions, Tregs kill or inactivate other T cells and APCs to augment suppre...

Full description

Saved in:
Bibliographic Details
Published in:Seminars in immunology 2011-12, Vol.23 (6), p.424-430
Main Authors: Yamaguchi, Tomoyuki, Wing, James B, Sakaguchi, Shimon
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
CTLA-4
Forkhead Transcription Factors - immunology
Foxp3
Humans
Immune suppression
Immune Tolerance
Inflammation - immunology
Interleukin-10
Interleukin-2
Models, Immunological
Regulatory T cells
T-Lymphocytes, Regulatory - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights ► Suppressive mechanisms mediated by CD4+ Foxp3+ regulatory T cells (Tregs) are reviewed. ► In physiological states, Tregs deprive co-stimuli from other T cells to suppress their activation. ► Under inflammatory conditions, Tregs kill or inactivate other T cells and APCs to augment suppression. ► The two modes of Treg-mediated suppression stably maintain immune homeostasis and self-tolerance.
ISSN:1044-5323
1096-3618
DOI:10.1016/j.smim.2011.10.002