Low frequency of Toll-like receptors 2 and 4 gene polymorphisms in Mexican patients and their association with Type 2 diabetes

Summary Type 2 diabetes (T2D) is characterized by a chronic low‐grade inflammatory state. SNP in Toll‐like receptor (TLR) genes has been associated with impaired inflammatory response. We genotyped the TLR4/D299G, TLR4/T399I and TLR2/R753Q polymorphisms. Low frequency was found with no association w...

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Bibliographic Details
Published in:International journal of immunogenetics 2011-12, Vol.38 (6), p.519-523
Main Authors: Maldonado-Bernal, C., Trejo-de la O, A., Sánchez-Contreras, M. E., Wacher-Rodarte, N., Torres, J., Cruz, M.
Format: Article
Language:English
Subjects:
Adult
Alleles
Diabetes mellitus
Diabetes Mellitus, Type 2 - genetics
Female
Gene Frequency - genetics
Gene polymorphism
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Inflammation
Male
Mexico
Polymorphism, Single Nucleotide - genetics
Single-nucleotide polymorphism
TLR2 protein
TLR4 protein
Toll-Like Receptor 2 - genetics
Toll-Like Receptor 4 - genetics
Toll-like receptors
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Summary:Summary Type 2 diabetes (T2D) is characterized by a chronic low‐grade inflammatory state. SNP in Toll‐like receptor (TLR) genes has been associated with impaired inflammatory response. We genotyped the TLR4/D299G, TLR4/T399I and TLR2/R753Q polymorphisms. Low frequency was found with no association with T2D, nevertheless the TLR2 SNP was associated with lower levels in HDL‐cholesterol values.
ISSN:1744-3121
1744-313X
DOI:10.1111/j.1744-313X.2011.01035.x