The administration of psilocybin to healthy, hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: a preliminary investigation of tolerability

This study sought to assess the tolerability of intravenously administered psilocybin in healthy, hallucinogen-experienced volunteers in a mock-magnetic resonance imaging environment as a preliminary stage to a controlled investigation using functional magnetic resonance imaging to explore the effec...

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Bibliographic Details
Published in:Journal of psychopharmacology (Oxford) 2011-11, Vol.25 (11), p.1562-1567
Main Authors: Carhart-Harris, Robin L, Williams, Tim M, Sessa, Ben, Tyacke, Robin J, Rich, Ann S, Feilding, Amanda, Nutt, David J
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood
Cerebrovascular Circulation - drug effects
Drug Tolerance
Female
Follow-Up Studies
Hallucinogens - administration & dosage
Humans
Injections, Intravenous - methods
Magnetic Resonance Imaging - methods
Male
Medical sciences
Middle Aged
Neuropharmacology
NMR
Nuclear magnetic resonance
Pharmacology. Drug treatments
Pilot Projects
Prescription drugs
Psilocybin - administration & dosage
Psychopharmacology
Side effects
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Summary:This study sought to assess the tolerability of intravenously administered psilocybin in healthy, hallucinogen-experienced volunteers in a mock-magnetic resonance imaging environment as a preliminary stage to a controlled investigation using functional magnetic resonance imaging to explore the effects of psilocybin on cerebral blood flow and activity. The present pilot study demonstrated that up to 2 mg of psilocybin delivered as a slow intravenous injection produces short-lived but typical drug effects that are psychologically and physiologically well tolerated. With appropriate care, this study supports the viability of functional magnetic resonance imaging work with psilocybin.
ISSN:0269-8811
1461-7285
DOI:10.1177/0269881110367445