Relationship between Apoptosis and Expression of Heat Shock Proteins in Peripheral Blood Lymphocytes of Patients with Myocardial Infarction

We studied activity and dynamics of apoptosis of peripheral blood lymphocytes in patients with myocardial infarction and analyzed the relationship of these processes with expression of heat shock proteins with a molecular weight of 70 kDa playing an essential role in preventing cell death. Thus, we...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2011-04, Vol.150 (6), p.682-684
Main Authors: Konstantinova, E. V., Khomyakova, N. F., Konstantinova, N. A., Podkolzina, A. V., Sapozhnikov, A. M.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Apoptosis
Biomedical and Life Sciences
Biomedicine
Case-Control Studies
Cell Biology
Female
Heart attack
Heat shock proteins
Heat-Shock Proteins - blood
Heat-Shock Proteins - metabolism
Humans
Internal Medicine
Laboratory Medicine
Lymphocytes
Lymphocytes - cytology
Male
Middle Aged
Myocardial Infarction - blood
Myocytes, Cardiac - pathology
Pathology
Proteins
Signal Transduction
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Summary:We studied activity and dynamics of apoptosis of peripheral blood lymphocytes in patients with myocardial infarction and analyzed the relationship of these processes with expression of heat shock proteins with a molecular weight of 70 kDa playing an essential role in preventing cell death. Thus, we first demonstrated activation of apoptosis in peripheral blood cells of patients with myocardial infarction compared to the control (healthy individuals) and revealed the expected negative correlation between the expression of heat shock proteins with a molecular weight of 70 kDa by lymphocytes and intensity of their death. The observed dynamics of mononuclear cell apoptosis in the peripheral blood of patients with myocardial infarction can reflect activity of programmed cardiomyocyte death in the focus of ischemic injury.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-011-1222-2