Preventive Efficacy of Oxidized Dextran and Pathomorphological Processes in Mouse Lungs in Avian Influenza A/H5N1

Oxidized dextran (60 kDa) exerts a pronounced preventive effect in laboratory mice infected with avian influenza subtype H5N1 A/Goose/Krasnoozerskoye/627/05 virus, which manifested in a significant increase in mouse lifetime (by 24.4%) and mortality rate (3.3-fold). This was probably related to sign...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2011-04, Vol.150 (6), p.707-710
Main Authors: Potapova, O. V., Shkurupiy, V. A., Sharkova, T. V., Troitskiy, A. V., Lusgina, N. G., Shestopalov, A. M.
Format: Article
Language:English
Subjects:
Animals
Antiviral agents
Avian influenza
Avian influenza viruses
Biomedical and Life Sciences
Biomedicine
Cell Biology
Dextran
Dextrans - administration & dosage
Dextrans - pharmacology
Fibrosis
Fowl plague
Hemodynamics
Infection
Inflammation
Influenza A Virus, H5N1 Subtype - pathogenicity
Internal Medicine
Laboratory Medicine
Lung
Lung - drug effects
Lung - pathology
Lung - virology
Male
Mice
Mortality
Orthomyxoviridae Infections - pathology
Orthomyxoviridae Infections - virology
Pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Oxidized dextran (60 kDa) exerts a pronounced preventive effect in laboratory mice infected with avian influenza subtype H5N1 A/Goose/Krasnoozerskoye/627/05 virus, which manifested in a significant increase in mouse lifetime (by 24.4%) and mortality rate (3.3-fold). This was probably related to significant alleviation of pathological changes in the lungs and severity of hemodynamic and inflammatory complications and early fibrosis.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-011-1229-8