Efficacy of Protamine Zinc Recombinant Human Insulin for Controlling Hyperglycemia in Dogs with Diabetes Mellitus

Background Alternative insulin preparations are needed when NPH insulin is ineffective in diabetic dogs. This study evaluated the efficacy of recombinant human protamine zinc insulin (rhPZI) for treating diabetic dogs. Hypothesis rhPZI is effective for treating diabetic dogs. Animals Six newly diagn...

Full description

Saved in:
Bibliographic Details
Published in:Journal of veterinary internal medicine 2012-01, Vol.26 (1), p.109-115
Main Authors: Maggiore, A. Della, Nelson, R. W., Dennis, J., Johnson, E., Kass, P. H.
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - metabolism
Body Weight - physiology
Diabetes Mellitus - blood
Diabetes Mellitus - drug therapy
Diabetes Mellitus - veterinary
Dog Diseases - blood
Dog Diseases - drug therapy
Dogs
Female
Fructosamine
Fructosamine - blood
Glucose
Hyperglycemia - blood
Hyperglycemia - drug therapy
Hyperglycemia - veterinary
Hypoglycemia
Hypoglycemic Agents - therapeutic use
Insulin, Isophane - therapeutic use
Male
Pancreas
Prospective Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Alternative insulin preparations are needed when NPH insulin is ineffective in diabetic dogs. This study evaluated the efficacy of recombinant human protamine zinc insulin (rhPZI) for treating diabetic dogs. Hypothesis rhPZI is effective for treating diabetic dogs. Animals Six newly diagnosed and 11 insulin‐treated diabetic dogs. Methods Prospective clinical trial. Dogs were treated with rhPZI for 60 days. Control of glycemia was assessed on days 7, 14, 30, and 60 by evaluation of history, physical examination, body weight, serum fructosamine concentration, and blood glucose concentrations measured before and 2, 4, 6, 8, and 10 hours after rhPZI administration. Adjustments in dosage of rhPZI were made as needed to control glycemia. Results rhPZI administration resulted in a significant decrease in 10‐hour mean blood glucose (MBG10h; 299 ± 115 versus 457 ± 38 mg/dL, X ± SD, P = .0003) and serum fructosamine (478 ± 83 versus 557 ± 104 μmol/L, P = .006) concentration at day 60, compared with day 1, respectively. By day 60, polyuria and polydipsia had improved in 14, body weight was stable or increased in 16, MBG10h had decreased in 16, and serum fructosamine concentration had decreased in 11 of 17 dogs, compared with day 1. Hypoglycemia (
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.2011.00861.x