Adverse systemic arterial function in patients with selenium deficiency

• Published in: The Journal of nutrition, health & aging health & aging, 2012, Vol.16 (1), p.85-88
• Main Authors: Chan, Y. -H., Siu, C. -W., Yiu, K. -H., Chan, H. -T., Li, S. -W., Tam, S., Cheung, B. M., Lau, C. -P., Lam, T. H., Tse, Hung-Fat
• Format: Article
• Language: English
• Subjects: Aged; Aging; Ankle Brachial Index; Biological and medical sciences; Blood Flow Velocity; Brachial Artery - physiopathology; Cardiology; Cardiovascular disease; Cardiovascular Diseases - etiology; Confounding Factors, Epidemiologic; Coronary vessels; Cross-Sectional Studies; Deficiency Diseases - complications; Deficiency Diseases - physiopathology; Diabetes; Diet Records; Energy Intake; Exercise; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Geriatrics/Gerontology; Heart failure; Hospitals; Humans; Hypertension; JNHA: Geriatric Science; Male; Medicine; Medicine & Public Health; Middle Aged; Neurosciences; Nutrition; Nutrition Assessment; Nutrition research; Outpatient care facilities; Primary Care Medicine; Quality of Life Research; Questionnaires; Selenium; Selenium - administration & dosage; Selenium - deficiency; Stroke; Surveys and Questionnaires; Trace Elements - deficiency; Vascular Diseases - etiology; Vascular Diseases - physiopathology; Vein & artery diseases; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 1279-7707; 1760-4788
• DOI: 10.1007/s12603-011-0086-5

Background Experimental studies have shown that selenium is involved in the synthesis of selenoproteins which might contribute to cardiovascular protection. However, the relationship between selenium deficiency and vascular function in clinical context remains unknown. Objective To investigate for any relationship between selenium deficiency and systemic arterial function in patients with high risk of vascular events. Design Cross-sectional study. Setting and Participants 306 consecutive patients with high risk for cardiovascular events (coronary artery disease 35%, acute/recurrent ischemic stroke 40%, diabetes mellitus 54%) followed up at internal medicine outpatient clinics. Measurements Non-invasive brachial-ankle pulse wave velocity (PWV) was determined using vascular profiling system (VP-2000). Long-term intake of selenium was determined by a validated food frequency questionnaire. Results Mean daily selenium intake was 59.5 ± 52.1 mcg/day, and mean PWV was 1782.4 ± 418.4 cm/s. Patients with selenium intake