Gold-mediated bifunctional modification of oligosaccharides via a three-component coupling reaction

An efficient modular approach for single-site incorporation of two independent functionalities (amines and alkynes) into aldehyde-containing oligosaccharides concurrently by using a one-pot gold-mediated three-component coupling reaction in aqueous medium under mild conditions has been developed.

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2012-02, Vol.10 (5), p.925-930
Main Authors: Kung, Karen Ka-Yan, Li, Gai-Li, Zou, Lan, Chong, Hiu-Chi, Leung, Yun-Chung, Wong, Ka-Hing, Lo, Vanessa Kar-Yan, Che, Chi-Ming, Wong, Man-Kin
Format: Article
Language:English
Subjects:
Aldehydes - chemistry
Alkynes - chemistry
Amines - chemistry
Gold - chemistry
Oligosaccharides - chemistry
Online Access:Get full text
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Description
Summary:An efficient modular approach for single-site incorporation of two independent functionalities (amines and alkynes) into aldehyde-containing oligosaccharides concurrently by using a one-pot gold-mediated three-component coupling reaction in aqueous medium under mild conditions has been developed.
ISSN:1477-0539
DOI:10.1039/c1ob06429k