A label-free electrochemical assay for quantification of gene-specific methylation in a nucleic acid sequence

A label-free electrochemical method is developed for simple and convenient quantification of gene-specific DNA hypermethylation in a DNA sequence without PCR amplification, bisulfite conversion or labeling processes.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (12), p.1769-1771
Main Authors: Dai, Zong, Hu, Xiao, Wu, Hai, Zou, Xiaoyong
Format: Article
Language:English
Subjects:
Base Sequence
Biosensing Techniques - methods
Bisulfite
DNA - chemistry
DNA Methylation
Electrochemical Techniques - methods
Nucleic Acid Hybridization - methods
Sensitivity and Specificity
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Description
Summary:A label-free electrochemical method is developed for simple and convenient quantification of gene-specific DNA hypermethylation in a DNA sequence without PCR amplification, bisulfite conversion or labeling processes.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc15398j