Thermoregulation: An Orphan Receptor Finds Its Way in the Cold

The hypometabolic state of torpor is a widely utilized and well-orchestrated response to food shortage. A new study shows that the melatonin-related orphan receptor GPR50 plays an important function in metabolic regulation for entry into torpor.

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Bibliographic Details
Published in:Current biology 2012-01, Vol.22 (1), p.R17-R18
Main Author: Swoap, Steven J.
Format: Article
Language:English
Subjects:
Animals
Body Temperature Regulation - physiology
cold
food shortages
Leptin - physiology
Male
Nerve Tissue Proteins - physiology
Receptors, G-Protein-Coupled - physiology
resting periods
thermoregulation
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Description
Summary:The hypometabolic state of torpor is a widely utilized and well-orchestrated response to food shortage. A new study shows that the melatonin-related orphan receptor GPR50 plays an important function in metabolic regulation for entry into torpor.
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2011.11.046