Case report of mammary analog secretory carcinoma of the parotid gland

Mammary Analog Secretory Carcinoma (MASC) is a new entity of malignant salivary gland tumors that morphologically resembles mammary secretory carcinoma and carries the identical ETV6‐NTRK3 fusion gene. We report our first case of MASC in Japan occurring in the parotid gland of a 37‐year‐old female p...

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Bibliographic Details
Published in:Pathology international 2012-02, Vol.62 (2), p.149-152
Main Authors: Ito, Shigemi, Ishida, Eiichi, Skalova, Alena, Matsuura, Kazuto, Kumamoto, Hiroyuki, Sato, Ikuro
Format: Article
Language:English
Subjects:
Adult
Carcinoma - pathology
Carcinoma - surgery
ETV6-NTRK3 translocation
Female
Humans
mammary analog secretory carcinoma
parotid gland
Parotid Neoplasms - pathology
Parotid Neoplasms - surgery
Treatment Outcome
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Summary:Mammary Analog Secretory Carcinoma (MASC) is a new entity of malignant salivary gland tumors that morphologically resembles mammary secretory carcinoma and carries the identical ETV6‐NTRK3 fusion gene. We report our first case of MASC in Japan occurring in the parotid gland of a 37‐year‐old female patient with a t (12; 15) (p13; q25) translocation. Histologically, the tumor was composed of monomorphic cuboidal cells with low‐grade vesicular nuclei and pale eosinophilic cytoplasm, and formed microcystic and tubular spaces with periodic acid‐Schiff‐positive secretion. Immunohistochemically, the tumor cells tested positive for cytokeratin, vimentin, and S‐100 protein. MASC is a morphological mimicker of acinic cell carcinoma, but is a distinct neoplasm characterized by a specific chromosomal translocation. An accumulation of similar case studies is mandatory in order to clarify biological behaviors.
ISSN:1320-5463
1440-1827
DOI:10.1111/j.1440-1827.2011.02759.x