SUMO playing tag with ubiquitin

In addition to being structurally related, the protein modifiers ubiquitin and SUMO (small ubiquitin-related modifier), share a multitude of functional interrelations. These include the targeting of the same attachment sites in certain substrates, and SUMO-dependent ubiquitylation in others. Notably...

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Bibliographic Details
Published in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2012, Vol.37 (1), p.23-31
Main Authors: Praefcke, Gerrit J.K., Hofmann, Kay, Dohmen, R. Jürgen
Format: Article
Language:English
Subjects:
Animals
cell growth
DNA Damage
enzymes
Enzymes - metabolism
equipment maintenance and repair
genome
Humans
pathogens
SUMO-1 Protein - metabolism
ubiquitin
Ubiquitins - metabolism
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Summary:In addition to being structurally related, the protein modifiers ubiquitin and SUMO (small ubiquitin-related modifier), share a multitude of functional interrelations. These include the targeting of the same attachment sites in certain substrates, and SUMO-dependent ubiquitylation in others. Notably, several cellular processes, including the targeting of repair machinery to DNA damage sites, require the sequential sumoylation and ubiquitylation of distinct substrates. Some proteins promote both modifications. By contrast, the activity of some enzymes that control either sumoylation or ubiquitylation is regulated by the respective other modification. In this review, we summarize recent findings regarding intersections between SUMO and ubiquitin that influence genome stability and cell growth and which are relevant in pathogen resistance and cancer treatment.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2011.09.002