Platelet rich plasma for the prevention of osteoradionecrosis. A double blinded randomized cross over controlled trial

Abstract Osteoradionecrosis of the jaws is a complication of radiotherapy and controversy remains about the management of teeth in the field of radiotherapy. Platelet rich plasma has been advocated in multiple surgical sites, both bone and soft tissue, to promote healing and reduce complications. A...

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Bibliographic Details
Published in:International journal of oral and maxillofacial surgery 2012-01, Vol.41 (1), p.2-4
Main Authors: Batstone, M.D, Cosson, J, Marquart, L, Acton, C
Format: Article
Language:English
Subjects:
Adult
Aged
Alveoloplasty - methods
Biological and medical sciences
Cross-Over Studies
dental extraction
Dentistry
Diseases of the osteoarticular system
Double-Blind Method
Female
Follow-Up Studies
Humans
Laryngeal Neoplasms - radiotherapy
Male
Mandible - pathology
Mandible - radiation effects
Mandibular Diseases - prevention & control
Medical sciences
Middle Aged
osteoradionecrosis
Osteoradionecrosis - prevention & control
Otorhinolaryngology. Stomatology
Pain Measurement
Pain, Postoperative - etiology
Pharyngeal Neoplasms - radiotherapy
platelet rich plasma
Platelet-Rich Plasma - physiology
radiotherapy
Radiotherapy Dosage
Surgery
Tooth Extraction
Tooth Socket - pathology
Tooth Socket - radiation effects
Vascular bone diseases
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Summary:Abstract Osteoradionecrosis of the jaws is a complication of radiotherapy and controversy remains about the management of teeth in the field of radiotherapy. Platelet rich plasma has been advocated in multiple surgical sites, both bone and soft tissue, to promote healing and reduce complications. A randomized double blinded controlled trial was performed on patients receiving bilateral radiotherapy that affected the mandible who required pre treatment dental extractions. One side received platelet rich plasma and the other acted as a control. Twenty-two patients were recruited over 12 months and over a 5-year period following treatment three developed osteoradionecrosis (14%). Platelet rich plasma failed to show any benefit in the prevention of osteoradionecrosis. Nor was there any benefit in pain scores or mucosal healing on sides that were treated with platelet rich plasma. Platelet rich plasma fails to show a benefit in the prevention of osteoradionecrosis. The rate of osteoradionecrosis is high compared to other published series and the prophylactic removal of molar teeth should be questioned as a preventative measure.
ISSN:0901-5027
1399-0020
DOI:10.1016/j.ijom.2011.06.018