Sebaceous hyperplasia: a pilot study to correlate this skin disease with circulating androgen levels

The sebaceous glands are susceptible to the effects of androgens. A benign proliferation of these hormones, i.e. hyperplasia, occurs with age. This was a pilot study to demonstrate whether any correlation exists between circulating androgen levels and an increase in the incidence of sebaceous hyperp...

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Bibliographic Details
Published in:Anais brasileiros de dermatología 2011-09, Vol.86 (5), p.917-923
Main Authors: Tagliolatto, Sandra, Alchorne, Mauricio M A, Enokihara, Mauro
Format: Article
Language:eng ; por
Subjects:
Adult
Aged
Androstenedione - blood
Biomarkers - blood
Case-Control Studies
Dihydrotestosterone - blood
Female
Humans
Hyperplasia - blood
Hyperplasia - pathology
Middle Aged
Pilot Projects
Prospective Studies
Sebaceous Gland Diseases - blood
Sebaceous Gland Diseases - pathology
Sebaceous Glands - pathology
Testosterone - blood
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Summary:The sebaceous glands are susceptible to the effects of androgens. A benign proliferation of these hormones, i.e. hyperplasia, occurs with age. This was a pilot study to demonstrate whether any correlation exists between circulating androgen levels and an increase in the incidence of sebaceous hyperplasia. Sixteen female patients with a diagnosis of sebaceous hyperplasia were compared to a control group of females of a similar age without the disease. Blood tests were performed on participants of both groups to measure circulating androgen levels (free and total testosterone and androstenedione levels). Results were tabulated for statistical analysis. These data showed no statistically significant differences in circulating androgen levels between the patients with sebaceous hyperplasia and the control group. These data suggest that no significant changes occur in circulating androgen levels [free and total testosterone, androstenedione, dehydroepiandrosterone (DHEA) and DHEA sulfate] in patients with sebaceous hyperplasia.
ISSN:1806-4841
DOI:10.1590/s0365-05962011000500009