Efficient one-pot preparation of novel fused chromeno[2,3- d]pyrimidine and pyrano[2,3- d]pyrimidine derivatives

• Published in: European journal of medicinal chemistry 2012, Vol.47 (1), p.18-23
• Main Authors: Aly, Hala M., Kamal, Mona M.
• Format: Article
• Language: English
• Subjects: Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antibacterial activity; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal activity; Antifungal agents; Aspergillus flavus - drug effects; Benzopyrans - chemical synthesis; Benzopyrans - chemistry; Benzopyrans - pharmacology; Biological and medical sciences; Candida albicans - drug effects; Chemistry Techniques, Synthetic - methods; Medical sciences; Pharmacology. Drug treatments; Pseudomonas aeruginosa - drug effects; Pyrans - chemical synthesis; Pyrans - chemistry; Pyrans - pharmacology; Pyrimidine; Pyrimidines - chemical synthesis; Pyrimidines - chemistry; Pyrimidines - pharmacology; Staphylococcus aureus - drug effects
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2011.09.040

Some novel chromeno[2,3- d]pyrimidinone, pyrano[2,3- d]pyrimidine, dihydropyrimidine, pyridopyranopyrimidine and pyrimidopyranopyrimidine have been synthesized. The structures of target compounds were confirmed by elemental analyses and spectral data. The antimicrobial activity of all the target synthesized compounds were tested against various microorganismst such as Pseudomonas aeruginosa; Staphylococcus aureus (Bacteria), Aspergillus flavus (Fungus) and Candida albicans (Yeast fungus) by the disc diffusion method. In general, the novel synthesized compounds showed a good antimicrobial activity against the previously mentioned microorganisms. Synthesis and Preliminary Antimicrobial Activity of Some New Pyrano[2,3- d]pyrimidine Derivatives. [Display omitted] ► Synthesized some novel pyrimidine derivatives. The structures of which were confirmed by elemental analyses and spectral data. ► The antimicrobial activity of all the target synthesized compounds was tested. ► We can conclude that the entire tested compounds are more active toward bacteria than fungi.