Unbalanced oxidative status in idiopathic sudden sensorineural hearing loss

An impaired cochlear perfusion seems to be an important etiopathogenetic event in idiopathic sudden sensorineural hearing loss (ISSNHL). Recently, oxidative stress has been proposed as risk factors of microvascular damage. This observational study aimed to evaluate the possible role of oxidative str...

Full description

Saved in:
Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2012-02, Vol.269 (2), p.449-453
Main Authors: Capaccio, Pasquale, Pignataro, Lorenzo, Gaini, Lorenzo M., Sigismund, Paolo E., Novembrino, Cristina, De Giuseppe, Rachele, Uva, Valentina, Tripodi, Armando, Bamonti, Fabrizia
Format: Article
Language:English
Subjects:
Adult
Antioxidants - metabolism
Auditory Threshold - physiology
Cochlea - blood supply
Endothelium, Vascular - physiopathology
Female
Head and Neck Surgery
Hearing Loss, Sudden - physiopathology
Humans
Male
Medicine
Medicine & Public Health
Microcirculation - physiology
Middle Aged
Neurosurgery
Otology
Otorhinolaryngology
Oxidative Stress - physiology
Reactive Oxygen Species - blood
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An impaired cochlear perfusion seems to be an important etiopathogenetic event in idiopathic sudden sensorineural hearing loss (ISSNHL). Recently, oxidative stress has been proposed as risk factors of microvascular damage. This observational study aimed to evaluate the possible role of oxidative stress in ISSNHL. In thirty-nine ISSNHL patients and seventy healthy subjects serum reactive oxygen species concentrations (ROS) and total antioxidant capacity (TAC) were measured by spectrophotometric methods on F.R.E.E. analyzer (Diacron International, Italy). Moreover, a global oxidative stress index (Oxidative-INDEX), reflecting both oxidative and antioxidant counterparts, was also calculated. 25/39 patients showed oxidative stress due to ROS levels significantly higher than controls (348.2 ± 84.8 vs. 306.75 ± 46.7 UCarr; p  = 0.001). The Oxidative-INDEX was significantly higher in patients than in controls (0.75 ± 2.4 vs. −0.0007 ± 1.28 AU, p  = 0.03). As oxidative stress is a key determinant in endothelial dysfunction, our findings could suggest vascular impairment involvement in ISSNHL etiopathogenesis.
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-011-1671-2