Oxygen dependence of metabolism and cellular adaptation in vertebrate muscles: a review

The key roles the cardiovascular system play in the complex distribution of blood, and consequently oxygen, have been extensively studied in vertebrates. Numerous studies have also revealed the complex and varied ways in which tissues cope with compromised oxygen supply. The links between these two...

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Bibliographic Details
Published in:Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology Biochemical, systemic, and environmental physiology, 2012-02, Vol.182 (2), p.177-188
Main Authors: Forgan, L. G., Forster, M. E.
Format: Article
Language:English
Subjects:
Adaptation
Adenosine triphosphate
Animal Physiology
Animals
Biochemistry
Biological Evolution
Biomedical and Life Sciences
Biomedicine
Blood
Cardiovascular system
Cell Hypoxia - physiology
Energy Metabolism - physiology
Hemoglobin
Human Physiology
Hypoxia
Life Sciences
Metabolism
Metabolites
Muscle, Skeletal - blood supply
Muscle, Skeletal - metabolism
Muscles
Nervous system
Oxygen
Oxygen - metabolism
Oxygenation
Phosphorylation
Physiology
Regional Blood Flow - physiology
Review
Smooth muscle
Species Specificity
Vertebrates
Vertebrates - metabolism
Vertebrates - physiology
Zoology
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Summary:The key roles the cardiovascular system play in the complex distribution of blood, and consequently oxygen, have been extensively studied in vertebrates. Numerous studies have also revealed the complex and varied ways in which tissues cope with compromised oxygen supply. The links between these two processes are the subject of much current research. This article aims to review how blood supply influences tissue oxygenation and affects metabolism, and how this might have played a role in the evolution of the complex muscle arrangements which characterise vertebrates. Muscle tissue is the greatest proportion of body mass in most vertebrates and undergoes dramatic alterations in metabolism and associated oxygen flux. Special attention is given to the myotome of fishes, in which the partitioning of the fibre types contrasts with the mosaic arrangement of tetrapods. This gives us the opportunity to study pure whole vascularised muscle blocks, rather than single fibres, and further explore the interrelationship between oxygen supply and tissue energetics.
ISSN:0174-1578
1432-136X
DOI:10.1007/s00360-011-0616-9