Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson's disease

Background: The A‐allele of the catechol‐O‐methyltransferase (COMT) Val158Met polymorphism is associated with decreased enzymatic activity and higher dopamine availability. Methods: We studied 219 patients with PD who were free of dyskinesias at baseline and underwent thorough annual examinations. R...

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Bibliographic Details
Published in:Movement disorders 2012-01, Vol.27 (1), p.132-135
Main Authors: de Lau, Lonneke M.L., Verbaan, Dagmar, Marinus, Johan, Heutink, Peter, van Hilten, Jacobus J.
Format: Article
Language:English
Subjects:
Aged
Antiparasitic Agents - adverse effects
Biological and medical sciences
Catechol O-Methyltransferase - genetics
Cohort Studies
COMT
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
dyskinesia
Dyskinesia, Drug-Induced - genetics
Dyskinesias - genetics
Female
Genetic Predisposition to Disease
genetics
Genotype
Humans
Male
Medical sciences
Methionine - genetics
Middle Aged
Neurology
Parkinson Disease - drug therapy
Parkinson Disease - genetics
Parkinson's disease
Polymorphism, Genetic - genetics
Proportional Hazards Models
Valine - genetics
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Summary:Background: The A‐allele of the catechol‐O‐methyltransferase (COMT) Val158Met polymorphism is associated with decreased enzymatic activity and higher dopamine availability. Methods: We studied 219 patients with PD who were free of dyskinesias at baseline and underwent thorough annual examinations. Results: The A‐allele of the COMT Val158Met polymorphism was related to an increased risk of developing dyskinesias during follow‐up, in a dose‐dependent manner (adjusted hazard ratios for the AG and AA genotypes [compared to GG]: 2.09 [95% confidence interval (CI), 1.07–4.06] and 2.81 [CI, 1.43–5.54], respectively). Conclusions: This finding suggests that genetic factors may affect susceptibility to dyskinesias in PD. © 2011 Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.23805