Comparison of three algorithms of non-invasive markers of fibrosis in chronic hepatitis C

Aliment Pharmacol Ther 2012; 35: 92–104 Summary Background  Preliminary data suggest that performance of non‐invasive markers for liver fibrosis in hepatitis C may improve when combined. Three algorithms based on the combination of Fibrotest, Forns’ index and AST‐to‐platelet ratio (APRI) have been p...

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Published in:Alimentary pharmacology & therapeutics 2012-01, Vol.35 (1), p.92-104
Main Authors: Sebastiani, G., Halfon, P., Castera, L., Mangia, A., Di Marco, V., Pirisi, M., Voiculescu, M., Bourliere, M., Alberti, A.
Format: Article
Language:English
Subjects:
Algorithms
alpha-Macroglobulins - metabolism
Apolipoprotein A-I - blood
Aspartate Aminotransferases - blood
Bilirubin - blood
Biological and medical sciences
Biomarkers - blood
Biopsy
Cholesterol - blood
Cirrhosis
Data processing
Digestive system
Female
Fibrosis
gamma-Glutamyltransferase - blood
Gastroenterology. Liver. Pancreas. Abdomen
Haptoglobins - metabolism
Hepatitis C
Hepatitis C - genetics
Hepatitis C virus
Hepatitis C, Chronic - blood
Hepatitis C, Chronic - diagnosis
Human viral diseases
Humans
Infectious diseases
Liver
Liver Cirrhosis - blood
Liver Cirrhosis - diagnosis
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Platelet Count
Polymerase Chain Reaction
Predictive Value of Tests
Retrospective Studies
RNA, Viral - blood
Sensitivity and Specificity
Viral diseases
Viral hepatitis
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Summary:Aliment Pharmacol Ther 2012; 35: 92–104 Summary Background  Preliminary data suggest that performance of non‐invasive markers for liver fibrosis in hepatitis C may improve when combined. Three algorithms based on the combination of Fibrotest, Forns’ index and AST‐to‐platelet ratio (APRI) have been proposed: Sequential Algorithm for Fibrosis Evaluation (SAFE biopsy); Fibropaca algorithm; Leroy algorithm. Aim  To compare three algorithms to diagnose significant fibrosis (≥F2 by METAVIR) and cirrhosis (F4). Methods  A total of 1013 HCV monoinfected cases undergoing liver biopsy were consecutively enrolled in seven centres. Fibrotest, APRI and Forns’ index were measured at the time of liver biopsy, considered the reference standard. Results  Overall, performance of combination algorithms was significantly higher than the single non‐invasive methods (P 
ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.2011.04897.x