The Arabidopsis Transcription Factor AtTCP15 Regulates Endoreduplication by Modulating Expression of Key Cell-cycle Genes

Plant cells frequently undergo endoreduplication, a modified cell cycle in which genome is repeatedly replicated without cytokinesis. As the key step to achieve final size and function for cells, endoreduplication is prevalent during plant development. However, mechanisms to control the balance betw...

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Bibliographic Details
Published in:Molecular plant 2012, Vol.5 (1), p.270-280
Main Authors: Li, Zi-Yu, Li, Bin, Dong, Ai-Wu
Format: Article
Language:English
Subjects:
Arabidopsis
Arabidopsis - genetics
Arabidopsis - growth & development
Arabidopsis - metabolism
Arabidopsis Proteins - genetics
Arabidopsis Proteins - metabolism
Cell cycle
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Cell division
Cell Nucleus Division
endoreduplication
Gene Duplication
gene expression
Gene Expression Regulation, Developmental
Gene Expression Regulation, Plant
Genes
Mitosis
Promoter Regions, Genetic
Protein Binding
TCP transcription factor
Transcription Factors - genetics
Transcription Factors - metabolism
基因表达
多倍体
植物细胞
生长发育过程
细胞周期
调控基因
转基因拟南芥
转录因子基因
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Summary:Plant cells frequently undergo endoreduplication, a modified cell cycle in which genome is repeatedly replicated without cytokinesis. As the key step to achieve final size and function for cells, endoreduplication is prevalent during plant development. However, mechanisms to control the balance between endoreduplication and mitotic cell division are still poorly understood. Here, we show that the Arabidopsis TCP (CINCINNATA-like TEOSINTE BRANCHED1-CYCLOIDEA-PCF)-family transcription factor gene AtTCP15 is expressed in trichomes, as well as in rapidly dividing and vascular tissues. Expression of AtTCP15SRDX, AtTCP15 fused with a SRDX repressor domain, induces extra endoreduplication in trichomes and cotyledon cells in transgenic Arabidopsis. On the contrary, overexpression of AtTCP15 suppresses endoreduplication in trichomes and other examined cells. Misregulation of AtTCP15 affects the expression of several important genes involved in cell-cycle regulation. AtTCP15 protein binds directly to the promoter regions of CYCA2;3 and RETINOBLASTOMA-RELATED (RBR) genes, which play key roles in endoreduplication. Taken together, AtTCP15 plays an important role in regulating endoreduplication during Arabidopsis development.
ISSN:1674-2052
1752-9867
DOI:10.1093/mp/ssr086