Regulatory effects of curcumin on lipid accumulation in monocytes/macrophages

Recent evidence suggests potential benefits from phytochemicals and micronutrients in protecting against atherosclerosis and inflammation, but the molecular mechanisms of these actions are still unclear. Here, we investigated whether the dietary polyphenol curcumin can modulate the accumulation of l...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2012-03, Vol.113 (3), p.833-840
Main Authors: Zingg, Jean-Marc, Hasan, Syeda T., Cowan, Danica, Ricciarelli, Roberta, Azzi, Angelo, Meydani, Mohsen
Format: Article
Language:English
Subjects:
Animals
CD36 Antigens - genetics
CD36 Antigens - metabolism
Cell Line
CURCUMIN
Curcumin - pharmacology
Diet, High-Fat
Fatty Acid-Binding Proteins - genetics
Fatty Acid-Binding Proteins - metabolism
Forkhead Transcription Factors - metabolism
FOXO3a
Lipid Metabolism - drug effects
LIPIDS
MACROPHAGES
Macrophages - drug effects
Macrophages - metabolism
Mice
Mice, Knockout
MONOCYTES
Monocytes - drug effects
Monocytes - metabolism
Phosphorylation - drug effects
Promoter Regions, Genetic
Receptors, LDL - genetics
TETRAHYDROCURCUMIN
Transcription, Genetic - drug effects
Up-Regulation
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Summary:Recent evidence suggests potential benefits from phytochemicals and micronutrients in protecting against atherosclerosis and inflammation, but the molecular mechanisms of these actions are still unclear. Here, we investigated whether the dietary polyphenol curcumin can modulate the accumulation of lipids in monocytes/macrophages. Curcumin increased the expression of two lipid transport genes, the fatty acids transporter CD36/FAT and the fatty acids binding protein 4 (FABP4/aP2; P 
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.23411