Comparison of dual-source 64-slice adenosine stress CT perfusion with stress-gated SPECT-MPI for evaluation of left ventricular function and volumes

• Published in: Journal of cardiovascular computed tomography 2012, Vol.6 (1), p.24-30
• Main Authors: Uthamalingam, Shanmugam, MD, Gurm, Gagandeep S., MD, Sidhu, Manavjot S., MD, Verdini, Daniel J., MD, Vorasettakarnkij, Yongkasem, MD, Engel, Leif-Christopher, MD, Blankstein, Ron, MD, Mamuya, Wilfred S., MD, Hoffman, Udo, MD, Brady, Thomas J., MD, Cury, Ricardo C., MD, Ghoshhajra, Brian B., MD, MBA
• Format: Article
• Language: English
• Subjects: Cardiac-Gated Imaging Techniques - methods; Cardiovascular; Coronary artery disease; Coronary Artery Disease - complications; Coronary Artery Disease - diagnosis; Female; Humans; Male; Middle Aged; Myocardial Perfusion Imaging - methods; Reproducibility of Results; Sensitivity and Specificity; Single-photon emission CT myocardial perfusion imaging, SPECT-MPI; Stress myocardial CT perfusion; Stress testing; Stroke Volume; Tomography, Emission-Computed, Single-Photon - methods; Tomography, X-Ray Computed - methods; Ventricular Dysfunction, Left - diagnosis; Ventricular Dysfunction, Left - etiology
• ISSN: 1934-5925; 1876-861X
• DOI: 10.1016/j.jcct.2011.10.016

Background Evaluation of left ventricular (LV) volumes and ejection fraction (LVEF) represent important components of pharmacologic stress imaging with either myocardial CT perfusion (CTP) or gated single-photon emission CT (SPECT) myocardial perfusion imaging (SPECT-MPI). Objectives We compared measurements of left ventricular function and volumes obtained with CTP and SPECT-MPI. Methods Forty-seven patients (mean age, 62 ± 11 years; male, n = 39) underwent stress CTP and SPECT-MPI. LVEF (in %), end-systolic volume (ESV; in mL), and end-diastolic volume (EDV; in mL) derived from stress CTP images were compared with SPECT-MPI. Results Stress CTP was in good agreement with SPECT-MPI for quantification of LVEF ( r = 0.91), EDV ( r = 0.75), and ESV ( r = 0.83; all P < 0.001). The mean LVEF measured by stress CTP (66% ± 17%) was similar to SPECT-MPI (64% ± 15%). Similar values were also derived for mean EDV (123 ± 30 mL vs 120 ± 34 mL) and ESV (44 ± 28 mL vs 51 ± 34 mL) for CTP and SPECT-MPI, respectively. Good agreement was also shown between both techniques for the assessment of regional wall motion with identical wall motion scores in 95.3% of the segments (κ = 0.79). Conclusions LVEF and LV volume parameters as determined by dual-source 64-slice adenosine stress CTP show a high correlation with values obtained with stress-gated SPECT-MPI.