Biological significance of fluctuating concentrations of carbon monoxide

The biological significance of fluctuating carbon monoxide concentrations is addressed. Fluctuation patterns can be approximated as a Fourier series of sine waves of different amplitudes, periods, and phases. A theoretical equation was derived for relating carboxyhemoglobin levels in blood to sine w...

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Bibliographic Details
Published in:Environmental science & technology 1986-09, Vol.20 (9), p.916-923
Main Authors: Saltzman, Bernard E, Fox, Stanley H
Format: Article
Language:English
Subjects:
Air
Biological and medical sciences
Environmental pollutants toxicology
Medical sciences
Toxicology
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Summary:The biological significance of fluctuating carbon monoxide concentrations is addressed. Fluctuation patterns can be approximated as a Fourier series of sine waves of different amplitudes, periods, and phases. A theoretical equation was derived for relating carboxyhemoglobin levels in blood to sine wave exposure patterns of Co. It was experimentally validated for rabbits exposed to 50-350 ppm Co in sine waves of periods in the 37-280 minute range. Higher frequency Co level fluctuations were more highly attenuated in the blood in accordance with the equation.
ISSN:0013-936X
1520-5851
DOI:10.1021/es00151a011