Biological significance of fluctuating concentrations of carbon monoxide

The biological significance of fluctuating carbon monoxide concentrations is addressed. Fluctuation patterns can be approximated as a Fourier series of sine waves of different amplitudes, periods, and phases. A theoretical equation was derived for relating carboxyhemoglobin levels in blood to sine w...

Full description

Saved in:
Bibliographic Details
Published in:Environmental science & technology 1986-09, Vol.20 (9), p.916-923
Main Authors: Saltzman, Bernard E, Fox, Stanley H
Format: Article
Language:English
Subjects:
Air
Biological and medical sciences
Environmental pollutants toxicology
Medical sciences
Toxicology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-a474t-42f2bf8ec8f039b67447cfef2c75675a601872f4790c5b02210533d2cd8c95f73
cites
container_end_page 923
container_issue 9
container_start_page 916
container_title Environmental science & technology
container_volume 20
creator Saltzman, Bernard E
Fox, Stanley H
description The biological significance of fluctuating carbon monoxide concentrations is addressed. Fluctuation patterns can be approximated as a Fourier series of sine waves of different amplitudes, periods, and phases. A theoretical equation was derived for relating carboxyhemoglobin levels in blood to sine wave exposure patterns of Co. It was experimentally validated for rabbits exposed to 50-350 ppm Co in sine waves of periods in the 37-280 minute range. Higher frequency Co level fluctuations were more highly attenuated in the blood in accordance with the equation.
doi_str_mv 10.1021/es00151a011
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_917576749</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>14207272</sourcerecordid><originalsourceid>FETCH-LOGICAL-a474t-42f2bf8ec8f039b67447cfef2c75675a601872f4790c5b02210533d2cd8c95f73</originalsourceid><addsrcrecordid>eNqN0c9PHCEUB3DS1NRVe_Ju5tDowUx9PIZh5tg11p9JTdSkN8KwsMHOgoWZRP_7YnZdPZjGE_D45EG-j5BdCt8pID0yCYByqoDST2RCOULJG04_k0mus7Jl9e9NspXSPQAgg-YL2UTEmjXIJ-Rs6kIf5k6rvkhu7p3NW69NEWxh-1EPoxqcnxc65KIfYj4Fn55vtYpd8MUi-PDoZmaHbFjVJ_N1tW6Tu58nt8dn5dWv0_PjH1elqkQ1lBVa7GxjdGOBtV0tqkpoayxqwWvBVQ20EWgr0YLmHSBS4IzNUM8a3XIr2DY5WPZ9iOHvaNIgFy5p0_fKmzAm2VLBRW7bZrn_X0nz08g5fAAiCBSY4eES6hhSisbKh-gWKj5JCvJ5FvLNLLLeW7Udu4WZre1L-Bl8WwGVcv425uBdWrsGKLC6yqxcMpcG87i-VvGPrAUTXN5e38iLG3F6Ob1s5fQ1IaWTvA9j9Hke7_7wH-sXq0E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14207272</pqid></control><display><type>article</type><title>Biological significance of fluctuating concentrations of carbon monoxide</title><source>ACS CRKN Legacy Archives</source><creator>Saltzman, Bernard E ; Fox, Stanley H</creator><creatorcontrib>Saltzman, Bernard E ; Fox, Stanley H</creatorcontrib><description>The biological significance of fluctuating carbon monoxide concentrations is addressed. Fluctuation patterns can be approximated as a Fourier series of sine waves of different amplitudes, periods, and phases. A theoretical equation was derived for relating carboxyhemoglobin levels in blood to sine wave exposure patterns of Co. It was experimentally validated for rabbits exposed to 50-350 ppm Co in sine waves of periods in the 37-280 minute range. Higher frequency Co level fluctuations were more highly attenuated in the blood in accordance with the equation.</description><identifier>ISSN: 0013-936X</identifier><identifier>EISSN: 1520-5851</identifier><identifier>DOI: 10.1021/es00151a011</identifier><identifier>PMID: 22263825</identifier><identifier>CODEN: ESTHAG</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Air ; Biological and medical sciences ; Environmental pollutants toxicology ; Medical sciences ; Toxicology</subject><ispartof>Environmental science &amp; technology, 1986-09, Vol.20 (9), p.916-923</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a474t-42f2bf8ec8f039b67447cfef2c75675a601872f4790c5b02210533d2cd8c95f73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/es00151a011$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/es00151a011$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,27041,27901,27902,56741,56791</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=8010364$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22263825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saltzman, Bernard E</creatorcontrib><creatorcontrib>Fox, Stanley H</creatorcontrib><title>Biological significance of fluctuating concentrations of carbon monoxide</title><title>Environmental science &amp; technology</title><addtitle>Environ. Sci. Technol</addtitle><description>The biological significance of fluctuating carbon monoxide concentrations is addressed. Fluctuation patterns can be approximated as a Fourier series of sine waves of different amplitudes, periods, and phases. A theoretical equation was derived for relating carboxyhemoglobin levels in blood to sine wave exposure patterns of Co. It was experimentally validated for rabbits exposed to 50-350 ppm Co in sine waves of periods in the 37-280 minute range. Higher frequency Co level fluctuations were more highly attenuated in the blood in accordance with the equation.</description><subject>Air</subject><subject>Biological and medical sciences</subject><subject>Environmental pollutants toxicology</subject><subject>Medical sciences</subject><subject>Toxicology</subject><issn>0013-936X</issn><issn>1520-5851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><recordid>eNqN0c9PHCEUB3DS1NRVe_Ju5tDowUx9PIZh5tg11p9JTdSkN8KwsMHOgoWZRP_7YnZdPZjGE_D45EG-j5BdCt8pID0yCYByqoDST2RCOULJG04_k0mus7Jl9e9NspXSPQAgg-YL2UTEmjXIJ-Rs6kIf5k6rvkhu7p3NW69NEWxh-1EPoxqcnxc65KIfYj4Fn55vtYpd8MUi-PDoZmaHbFjVJ_N1tW6Tu58nt8dn5dWv0_PjH1elqkQ1lBVa7GxjdGOBtV0tqkpoayxqwWvBVQ20EWgr0YLmHSBS4IzNUM8a3XIr2DY5WPZ9iOHvaNIgFy5p0_fKmzAm2VLBRW7bZrn_X0nz08g5fAAiCBSY4eES6hhSisbKh-gWKj5JCvJ5FvLNLLLeW7Udu4WZre1L-Bl8WwGVcv425uBdWrsGKLC6yqxcMpcG87i-VvGPrAUTXN5e38iLG3F6Ob1s5fQ1IaWTvA9j9Hke7_7wH-sXq0E</recordid><startdate>19860901</startdate><enddate>19860901</enddate><creator>Saltzman, Bernard E</creator><creator>Fox, Stanley H</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7TV</scope><scope>7X8</scope></search><sort><creationdate>19860901</creationdate><title>Biological significance of fluctuating concentrations of carbon monoxide</title><author>Saltzman, Bernard E ; Fox, Stanley H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a474t-42f2bf8ec8f039b67447cfef2c75675a601872f4790c5b02210533d2cd8c95f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Air</topic><topic>Biological and medical sciences</topic><topic>Environmental pollutants toxicology</topic><topic>Medical sciences</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saltzman, Bernard E</creatorcontrib><creatorcontrib>Fox, Stanley H</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental science &amp; technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saltzman, Bernard E</au><au>Fox, Stanley H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biological significance of fluctuating concentrations of carbon monoxide</atitle><jtitle>Environmental science &amp; technology</jtitle><addtitle>Environ. Sci. Technol</addtitle><date>1986-09-01</date><risdate>1986</risdate><volume>20</volume><issue>9</issue><spage>916</spage><epage>923</epage><pages>916-923</pages><issn>0013-936X</issn><eissn>1520-5851</eissn><coden>ESTHAG</coden><abstract>The biological significance of fluctuating carbon monoxide concentrations is addressed. Fluctuation patterns can be approximated as a Fourier series of sine waves of different amplitudes, periods, and phases. A theoretical equation was derived for relating carboxyhemoglobin levels in blood to sine wave exposure patterns of Co. It was experimentally validated for rabbits exposed to 50-350 ppm Co in sine waves of periods in the 37-280 minute range. Higher frequency Co level fluctuations were more highly attenuated in the blood in accordance with the equation.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>22263825</pmid><doi>10.1021/es00151a011</doi><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0013-936X
ispartof Environmental science & technology, 1986-09, Vol.20 (9), p.916-923
issn 0013-936X
1520-5851
language eng
recordid cdi_proquest_miscellaneous_917576749
source ACS CRKN Legacy Archives
subjects Air
Biological and medical sciences
Environmental pollutants toxicology
Medical sciences
Toxicology
title Biological significance of fluctuating concentrations of carbon monoxide
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T10%3A51%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Biological%20significance%20of%20fluctuating%20concentrations%20of%20carbon%20monoxide&rft.jtitle=Environmental%20science%20&%20technology&rft.au=Saltzman,%20Bernard%20E&rft.date=1986-09-01&rft.volume=20&rft.issue=9&rft.spage=916&rft.epage=923&rft.pages=916-923&rft.issn=0013-936X&rft.eissn=1520-5851&rft.coden=ESTHAG&rft_id=info:doi/10.1021/es00151a011&rft_dat=%3Cproquest_cross%3E14207272%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-a474t-42f2bf8ec8f039b67447cfef2c75675a601872f4790c5b02210533d2cd8c95f73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=14207272&rft_id=info:pmid/22263825&rfr_iscdi=true