Outcome of Percutaneous Coronary Intervention Utilizing Drug-Eluting Stents in Patients With Reduced Left Ventricular Ejection Fraction

• Published in: The American journal of cardiology 2012-02, Vol.109 (3), p.344-351
• Main Authors: Sardi, Gabriel L., MD, Gaglia, Michael A., MD, MSc, Maluenda, Gabriel, MD, Torguson, Rebecca, MPH, Laynez-Carnicero, Ana, MD, Ben-Dor, Itsik, MD, Hauville, Camille, MD, Xue, Zhenyi, MS, Suddath, William O., MD, Kent, Kenneth M., MD, PhD, Satler, Lowell F., MD, Pichard, Augusto D., MD, Lindsay, Joseph, MD, Waksman, Ron, MD
• Format: Article
• Language: English
• Subjects: Aged; Angioplasty, Balloon, Coronary - methods; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Cardiovascular system; Cause of Death - trends; Clinical outcomes; Coronary Angiography; Diseases of the cardiovascular system; District of Columbia - epidemiology; Drug-Eluting Stents; Echocardiography; Electrocardiography; Female; Follow-Up Studies; Gated Blood-Pool Imaging; Humans; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Medical treatment; Middle Aged; Myocardial Ischemia - complications; Myocardial Ischemia - mortality; Myocardial Ischemia - surgery; Prognosis; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Retrospective Studies; Risk Factors; Stents; Stroke Volume; Survival Rate - trends; Thrombosis; Treatment Outcome; Ventricular Dysfunction, Left - complications; Ventricular Dysfunction, Left - mortality; Ventricular Dysfunction, Left - physiopathology
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2011.09.016

Ischemic cardiomyopathy with depressed left ventricular ejection fraction (LVEF) is predictive of death after percutaneous coronary intervention (PCI), but its association with stent thrombosis (ST) and the need for repeat revascularization is less clearly defined. In total 5,377 patients undergoing PCI were retrospectively evaluated. Multivariable Cox proportional hazards regression and competitive outcome analysis were employed. The primary end point was 1-year major adverse cardiac events (all-cause death, Q-wave myocardial infarction, ST, and target lesion revascularization [TLR]). Individual end points of ST and of TLR were also evaluated. Patients with normal LVEF (>50%) were compared to those with mild (41% to 50%), moderate (25% to 40%), and severe (