Unexpectedly high frequency of European parentage in Venezuelan patients with chronic lymphocytic leukemia

Abstract There is insufficient information on the characteristics of chronic lymphocytic leukemia (CLL) in Latin American patients. Immunoglobulin variable-region heavy-chain (IGVH) gene usage and mutation status and prognostic factors were investigated in patients resident in Venezuela. The most fr...

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Bibliographic Details
Published in:Leukemia & lymphoma 2012-02, Vol.53 (2), p.235-241
Main Authors: Marquez, Maria-Elena, Deglesne, Pierre-Antoine, Lopez, Jose Luis, Costa, Osiris Da, Borrego, Mildred, Hernández, Marcos, Muller, Aixa, Ajchenbaum-Cymbalista, Florence, Romano, Egidio
Format: Article
Language:English
Subjects:
ADP-ribosyl Cyclase 1 - metabolism
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
CD38 antigen
Chronic lymphocytic leukemia
Complementarity Determining Regions - genetics
European Continental Ancestry Group - genetics
Female
Flow Cytometry
Humans
IGVH mutational status
Immunoglobulin Heavy Chains - genetics
Immunoglobulin Variable Region - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis
Leukemia, Lymphocytic, Chronic, B-Cell - ethnology
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Male
Membrane Glycoproteins - metabolism
Middle Aged
Mutation - genetics
Neoplasm Staging
Prognosis
Venezuela - ethnology
ZAP-70
ZAP-70 Protein-Tyrosine Kinase - metabolism
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Summary:Abstract There is insufficient information on the characteristics of chronic lymphocytic leukemia (CLL) in Latin American patients. Immunoglobulin variable-region heavy-chain (IGVH) gene usage and mutation status and prognostic factors were investigated in patients resident in Venezuela. The most frequently used IGVH family genes were: VH3 > VH1 > VH4 > VH5, with a high incidence of IGVH1.69 and IGVH3.21 genes, and 55.2% of IGVH genes were mutated. Analysis of HCDR3 (third complementarity-determining region of the heavy chain) revealed that 24% of Venezuelan HCDR3s belonged to a CLL stereotyped HCDR3. Results for prognostic factors were similar to those reported previously for Caucasian populations. Interestingly, we found an over-representation of people of European extraction among Venezuelan patients with CLL, suggesting the possibility of a higher frequency of susceptibility genes for CLL in Europeans in comparison with Latin American mestizos.
ISSN:1042-8194
1029-2403
DOI:10.3109/10428194.2011.606938