Sugarcane biopolymer patch in femoral vein angioplasty on dogs

• Published in: Journal of vascular surgery 2012-02, Vol.55 (2), p.517-521
• Main Authors: de Barros-Marques, Silvio Romero, PhD, Marques-Lins, Esdras, PhD, de Albuquerque, Maria Cláudia Sodré, PhD, de Andrade-Aguiar, José Lamartine, PhD
• Format: Article
• Language: English
• Subjects: Angioplasty - adverse effects; Angioplasty - instrumentation; Animals; Biological and medical sciences; Biopolymers; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation - adverse effects; Blood Vessel Prosthesis Implantation - instrumentation; Dogs; Female; Femoral Vein - diagnostic imaging; Femoral Vein - pathology; Fibrosis; Laser-Doppler Flowmetry; Male; Medical sciences; Membranes, Artificial; Phlebography; Polytetrafluoroethylene; Prosthesis Design; Saccharum; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the heart; Time Factors; Ultrasonography; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels
• ISSN: 0741-5214; 1097-6809
• DOI: 10.1016/j.jvs.2011.05.047

Purpose To evaluate the use of the sugarcane biopolymer membrane in femoral vein patch angioplasty on dogs. Methods Eight dogs were submitted to bilateral femoral vein patch angioplasty with a sugarcane biopolymer membrane patch on one side and an expanded polytetrafluoroethylene (e-PTFE) patch on the contralateral side. This research was performed at Experimental Surgical Research Laboratory of the Centro de Ciências da Saúde at Universidade Federal de Pernambuco. The dogs underwent new surgery at 180 days after the patch angioplasty in order to harvest the femoral vein. All the animals were evaluated by clinical examination, measure of femoral vein diameter, venogram, and Doppler fluxometry. The material harvested was sent for histologic study. Each animal served as its own control. Results In all veins of both groups, there were no cases of infection, rupture, or pseudoaneurysm formation and thrombosis. In both groups, a chronic inflammatory reaction was observed, with lymphocytes, neutrophils, and fibrosis in the outer surface of the patches. Fibrosis was seen in the inner surfaces of all the patches. In e-PTFE patches, invasion by fibroblasts occurred. Conclusions The sugarcane biopolymer membrane can be used as a patch in femoral vein angioplasty on dogs.