The effects of hydroxysafflor yellow A on blood pressure and cardiac function

• Published in: Journal of ethnopharmacology 2012-02, Vol.139 (3), p.746-750
• Main Authors: Nie, Pei-He, Zhang, Lin, Zhang, Wen-Hui, Rong, Wei-Fang, Zhi, Jian-Ming
• Format: Article
• Language: English
• Subjects: Animals; Antihypertensive; Antihypertensive Agents - pharmacology; Antihypertensive Agents - therapeutic use; blood pressure; Blood Pressure - drug effects; Calcium Channel Blockers - pharmacology; Calcium Channel Blockers - therapeutic use; Calcium Channels; cardiac output; Carthamus tinctorius; Chalcone - analogs & derivatives; Chalcone - pharmacology; Chalcone - therapeutic use; Dose-Response Relationship, Drug; Flowers; heart; heart rate; Heart Rate - drug effects; Hydroxyl safflor yellow A; Hypertension - drug therapy; intravenous injection; Isolated perfused hearts; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Potassium Channel Blockers - pharmacology; Potassium Channel Blockers - therapeutic use; potassium channels; Potassium Channels - drug effects; Quinones - pharmacology; Quinones - therapeutic use; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reference Values; Ventricular Function, Left - drug effects
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2011.11.054

AIM OF THE STUDY: This work aims to investigate the effects of HSYA on cardiac function and blood pressure. MATERIALS AND METHODS: To evaluate changes in mean arterial pressure (MAP) and heart rate (HR), different groups of pentobarbitone-anesthetized normotensive and spontaneously hypertensive rats (SHR) were treated with intravenous HSYA (0.1–3mg/kg). Isolated WKY rat hearts in Langendorff system were employed for examining the effect of HSYA on hemodynamic. After 30min equilibration time the isolated hearts were perfused with HSYA (30μmol/L) in a stepwise fashion. Potassium channel inhibitors were used to determine the role of potassium channel activation in HSYA effect. RESULTS: Intravenous injection of the HSYA significantly reduced MAP and HR in both normotensive rats and SHR in a dose-dependent manner. HSYA reduced left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), the maximum rate of increase of left ventricular pressure (+dp/dtₘₐₓ) and heart rate (HR) in a dose-dependent manner. HSYA had no remarkable effect on the maximum rate of decrease of left ventricular pressure (−dp/dtₘₐₓ); BKCₐ and KATP blocker can weakened the inhibitory effect of HSYA on heart function and HR, but KV and KACₕ blocker did not significantly weaken the HSYA effects. CONCLUSION: Our results show that HSYA could significantly reduce blood pressure and heart rate, which may be related to activation of BKCₐ and KATP channels.