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Serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease

Abstract Objective There are no data on the relationship between serum paraoxonase-3 (PON3) concentration and atherosclerosis in humans. Our aim was to investigate possible associations, using recently developed methods, in patients with peripheral artery disease (PAD) or coronary artery disease (CA...

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Published in:Atherosclerosis 2012-02, Vol.220 (2), p.545-551
Main Authors: Rull, Anna, García, Raúl, Fernández-Sender, Laura, García-Heredia, Anabel, Aragonès, Gerard, Beltrán-Debón, Raúl, Marsillach, Judit, Alegret, Josep M, Martín-Paredero, Vicente, Mackness, Bharti, Mackness, Michael, Joven, Jorge, Camps, Jordi
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cited_by cdi_FETCH-LOGICAL-c497t-c0c81e4e117ba1612ac03d22e4df8a829c7a10807f6abb265b77b8ad95ad3e273
cites cdi_FETCH-LOGICAL-c497t-c0c81e4e117ba1612ac03d22e4df8a829c7a10807f6abb265b77b8ad95ad3e273
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container_title Atherosclerosis
container_volume 220
creator Rull, Anna
García, Raúl
Fernández-Sender, Laura
García-Heredia, Anabel
Aragonès, Gerard
Beltrán-Debón, Raúl
Marsillach, Judit
Alegret, Josep M
Martín-Paredero, Vicente
Mackness, Bharti
Mackness, Michael
Joven, Jorge
Camps, Jordi
description Abstract Objective There are no data on the relationship between serum paraoxonase-3 (PON3) concentration and atherosclerosis in humans. Our aim was to investigate possible associations, using recently developed methods, in patients with peripheral artery disease (PAD) or coronary artery disease (CAD). Methods We studied 118 PAD and 72 CAD patients and 175 healthy volunteers. Serum PON3 was determined by in-house ELISA using polyclonal antibodies generated against a synthetic peptide with a sequence specific to PON3. Polymorphisms of the PON3 promoter were analysed by the Iplex Gold MassArray™ method. Results There was a significant increase in serum PON3 concentration in both groups of patients with respect to the control group. In PAD patients, we observed significant positive correlations between PON3, insulin levels and HOMA index. These associations were not observed in CAD. There were significant positive associations between serum PON3 and β-2-microglobulin, CCL2 and high-sensitivity C-reactive protein in CAD patients, but not in PAD. We did not find any significant differences in PON3 gene promoter polymorphisms and their haplotypes between patients and controls, indicating that associations were not genetically determined. Conclusion In both atherosclerotic phenotypes, serum PON3 concentration was increased, but this was associated with decreased insulin sensitivity in PAD and with inflammation in CAD.
doi_str_mv 10.1016/j.atherosclerosis.2011.11.021
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Our aim was to investigate possible associations, using recently developed methods, in patients with peripheral artery disease (PAD) or coronary artery disease (CAD). Methods We studied 118 PAD and 72 CAD patients and 175 healthy volunteers. Serum PON3 was determined by in-house ELISA using polyclonal antibodies generated against a synthetic peptide with a sequence specific to PON3. Polymorphisms of the PON3 promoter were analysed by the Iplex Gold MassArray™ method. Results There was a significant increase in serum PON3 concentration in both groups of patients with respect to the control group. In PAD patients, we observed significant positive correlations between PON3, insulin levels and HOMA index. These associations were not observed in CAD. There were significant positive associations between serum PON3 and β-2-microglobulin, CCL2 and high-sensitivity C-reactive protein in CAD patients, but not in PAD. We did not find any significant differences in PON3 gene promoter polymorphisms and their haplotypes between patients and controls, indicating that associations were not genetically determined. Conclusion In both atherosclerotic phenotypes, serum PON3 concentration was increased, but this was associated with decreased insulin sensitivity in PAD and with inflammation in CAD.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2011.11.021</identifier><identifier>PMID: 22153698</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Aged ; Aged, 80 and over ; Antioxidants ; Aryldialkylphosphatase - blood ; Aryldialkylphosphatase - genetics ; Atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; blood serum ; C-reactive protein ; Cardiology. Vascular system ; Cardiovascular ; Case-Control Studies ; coronary artery disease ; Coronary Artery Disease - blood ; Coronary Artery Disease - enzymology ; Coronary Artery Disease - genetics ; Coronary Artery Disease - immunology ; Coronary heart disease ; Cross-Sectional Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; genes ; Haplotypes ; Heart ; Humans ; inflammation ; Inflammation - blood ; Inflammation - enzymology ; Inflammation - physiopathology ; Inflammation Mediators - blood ; insulin ; Insulin Resistance ; Linkage Disequilibrium ; Lipoproteins ; Male ; Medical sciences ; Middle Aged ; Myocardial infarction ; Paraoxonases ; patients ; Peripheral Arterial Disease - blood ; Peripheral Arterial Disease - enzymology ; Peripheral Arterial Disease - genetics ; Peripheral Arterial Disease - physiopathology ; Peripheral vascular disease ; Phenotype ; Pilot Projects ; polyclonal antibodies ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Spain ; Up-Regulation ; volunteers</subject><ispartof>Atherosclerosis, 2012-02, Vol.220 (2), p.545-551</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2011 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-c0c81e4e117ba1612ac03d22e4df8a829c7a10807f6abb265b77b8ad95ad3e273</citedby><cites>FETCH-LOGICAL-c497t-c0c81e4e117ba1612ac03d22e4df8a829c7a10807f6abb265b77b8ad95ad3e273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=25455032$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22153698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rull, Anna</creatorcontrib><creatorcontrib>García, Raúl</creatorcontrib><creatorcontrib>Fernández-Sender, Laura</creatorcontrib><creatorcontrib>García-Heredia, Anabel</creatorcontrib><creatorcontrib>Aragonès, Gerard</creatorcontrib><creatorcontrib>Beltrán-Debón, Raúl</creatorcontrib><creatorcontrib>Marsillach, Judit</creatorcontrib><creatorcontrib>Alegret, Josep M</creatorcontrib><creatorcontrib>Martín-Paredero, Vicente</creatorcontrib><creatorcontrib>Mackness, Bharti</creatorcontrib><creatorcontrib>Mackness, Michael</creatorcontrib><creatorcontrib>Joven, Jorge</creatorcontrib><creatorcontrib>Camps, Jordi</creatorcontrib><title>Serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Abstract Objective There are no data on the relationship between serum paraoxonase-3 (PON3) concentration and atherosclerosis in humans. Our aim was to investigate possible associations, using recently developed methods, in patients with peripheral artery disease (PAD) or coronary artery disease (CAD). Methods We studied 118 PAD and 72 CAD patients and 175 healthy volunteers. Serum PON3 was determined by in-house ELISA using polyclonal antibodies generated against a synthetic peptide with a sequence specific to PON3. Polymorphisms of the PON3 promoter were analysed by the Iplex Gold MassArray™ method. Results There was a significant increase in serum PON3 concentration in both groups of patients with respect to the control group. In PAD patients, we observed significant positive correlations between PON3, insulin levels and HOMA index. These associations were not observed in CAD. There were significant positive associations between serum PON3 and β-2-microglobulin, CCL2 and high-sensitivity C-reactive protein in CAD patients, but not in PAD. We did not find any significant differences in PON3 gene promoter polymorphisms and their haplotypes between patients and controls, indicating that associations were not genetically determined. Conclusion In both atherosclerotic phenotypes, serum PON3 concentration was increased, but this was associated with decreased insulin sensitivity in PAD and with inflammation in CAD.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antioxidants</subject><subject>Aryldialkylphosphatase - blood</subject><subject>Aryldialkylphosphatase - genetics</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood and lymphatic vessels</subject><subject>blood serum</subject><subject>C-reactive protein</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Case-Control Studies</subject><subject>coronary artery disease</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - enzymology</subject><subject>Coronary Artery Disease - genetics</subject><subject>Coronary Artery Disease - immunology</subject><subject>Coronary heart disease</subject><subject>Cross-Sectional Studies</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>genes</subject><subject>Haplotypes</subject><subject>Heart</subject><subject>Humans</subject><subject>inflammation</subject><subject>Inflammation - blood</subject><subject>Inflammation - enzymology</subject><subject>Inflammation - physiopathology</subject><subject>Inflammation Mediators - blood</subject><subject>insulin</subject><subject>Insulin Resistance</subject><subject>Linkage Disequilibrium</subject><subject>Lipoproteins</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial infarction</subject><subject>Paraoxonases</subject><subject>patients</subject><subject>Peripheral Arterial Disease - blood</subject><subject>Peripheral Arterial Disease - enzymology</subject><subject>Peripheral Arterial Disease - genetics</subject><subject>Peripheral Arterial Disease - physiopathology</subject><subject>Peripheral vascular disease</subject><subject>Phenotype</subject><subject>Pilot Projects</subject><subject>polyclonal antibodies</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Promoter Regions, Genetic</subject><subject>Spain</subject><subject>Up-Regulation</subject><subject>volunteers</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNksFu1DAQhiMEokvhFcCXilMW24nj5AASqmhBqsRh6dmaOBPqJXEW2ynsi_C8nWiXlegJybIl65t_Rv6cZReCrwUX1bvtGtIdhinaYdldXEsuxJoWl-JJthK1bnJR1uXTbMXpKm-E4mfZixi3nPNSi_p5dialUEXV1KvszwbDPLIdBJh-Tx4i5gWzk7foU4DkJs9cZBDjZB0k7Ngvl-6Y83EenGcRfXTJ3bu0pzu2w-B2NBwMDELCsGedi0iZDPypsh9gHI_JnloF6krkvwUvs2c9DBFfHc_z7Pbq07fLz_nN1-svlx9vcls2OuWW21pgiULoFkQlJFhedFJi2fU11LKxGgSvue4raFtZqVbrtoauUdAVKHVxnr095O7C9HPGmMzoosVhAI_THE0jtNKN0iWR7w-kpVePAXuzC26kyY3gZjFjtuaRGbOYMbRIA9W_Pnaa2xG7U_VfFQRcHAGIFoY-gLeUceJUqRQvJHFvDlwPk4HvgZjbDXVSi95a8YW4PhBIL3fvMJhoHZLSzgW0yXST---hPzxKsqTd0Xg_cI9xO83Bkx4jTJSGm83y4Zb_JiibN7IqHgAXudjr</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Rull, Anna</creator><creator>García, Raúl</creator><creator>Fernández-Sender, Laura</creator><creator>García-Heredia, Anabel</creator><creator>Aragonès, Gerard</creator><creator>Beltrán-Debón, Raúl</creator><creator>Marsillach, Judit</creator><creator>Alegret, Josep M</creator><creator>Martín-Paredero, Vicente</creator><creator>Mackness, Bharti</creator><creator>Mackness, Michael</creator><creator>Joven, Jorge</creator><creator>Camps, Jordi</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>Serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease</title><author>Rull, Anna ; García, Raúl ; Fernández-Sender, Laura ; García-Heredia, Anabel ; Aragonès, Gerard ; Beltrán-Debón, Raúl ; Marsillach, Judit ; Alegret, Josep M ; Martín-Paredero, Vicente ; Mackness, Bharti ; Mackness, Michael ; Joven, Jorge ; Camps, Jordi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-c0c81e4e117ba1612ac03d22e4df8a829c7a10807f6abb265b77b8ad95ad3e273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antioxidants</topic><topic>Aryldialkylphosphatase - blood</topic><topic>Aryldialkylphosphatase - genetics</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood and lymphatic vessels</topic><topic>blood serum</topic><topic>C-reactive protein</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Case-Control Studies</topic><topic>coronary artery disease</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - enzymology</topic><topic>Coronary Artery Disease - genetics</topic><topic>Coronary Artery Disease - immunology</topic><topic>Coronary heart disease</topic><topic>Cross-Sectional Studies</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>genes</topic><topic>Haplotypes</topic><topic>Heart</topic><topic>Humans</topic><topic>inflammation</topic><topic>Inflammation - blood</topic><topic>Inflammation - enzymology</topic><topic>Inflammation - physiopathology</topic><topic>Inflammation Mediators - blood</topic><topic>insulin</topic><topic>Insulin Resistance</topic><topic>Linkage Disequilibrium</topic><topic>Lipoproteins</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial infarction</topic><topic>Paraoxonases</topic><topic>patients</topic><topic>Peripheral Arterial Disease - blood</topic><topic>Peripheral Arterial Disease - enzymology</topic><topic>Peripheral Arterial Disease - genetics</topic><topic>Peripheral Arterial Disease - physiopathology</topic><topic>Peripheral vascular disease</topic><topic>Phenotype</topic><topic>Pilot Projects</topic><topic>polyclonal antibodies</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Promoter Regions, Genetic</topic><topic>Spain</topic><topic>Up-Regulation</topic><topic>volunteers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rull, Anna</creatorcontrib><creatorcontrib>García, Raúl</creatorcontrib><creatorcontrib>Fernández-Sender, Laura</creatorcontrib><creatorcontrib>García-Heredia, Anabel</creatorcontrib><creatorcontrib>Aragonès, Gerard</creatorcontrib><creatorcontrib>Beltrán-Debón, Raúl</creatorcontrib><creatorcontrib>Marsillach, Judit</creatorcontrib><creatorcontrib>Alegret, Josep M</creatorcontrib><creatorcontrib>Martín-Paredero, Vicente</creatorcontrib><creatorcontrib>Mackness, Bharti</creatorcontrib><creatorcontrib>Mackness, Michael</creatorcontrib><creatorcontrib>Joven, Jorge</creatorcontrib><creatorcontrib>Camps, Jordi</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rull, Anna</au><au>García, Raúl</au><au>Fernández-Sender, Laura</au><au>García-Heredia, Anabel</au><au>Aragonès, Gerard</au><au>Beltrán-Debón, Raúl</au><au>Marsillach, Judit</au><au>Alegret, Josep M</au><au>Martín-Paredero, Vicente</au><au>Mackness, Bharti</au><au>Mackness, Michael</au><au>Joven, Jorge</au><au>Camps, Jordi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>220</volume><issue>2</issue><spage>545</spage><epage>551</epage><pages>545-551</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Abstract Objective There are no data on the relationship between serum paraoxonase-3 (PON3) concentration and atherosclerosis in humans. Our aim was to investigate possible associations, using recently developed methods, in patients with peripheral artery disease (PAD) or coronary artery disease (CAD). Methods We studied 118 PAD and 72 CAD patients and 175 healthy volunteers. Serum PON3 was determined by in-house ELISA using polyclonal antibodies generated against a synthetic peptide with a sequence specific to PON3. Polymorphisms of the PON3 promoter were analysed by the Iplex Gold MassArray™ method. Results There was a significant increase in serum PON3 concentration in both groups of patients with respect to the control group. In PAD patients, we observed significant positive correlations between PON3, insulin levels and HOMA index. These associations were not observed in CAD. There were significant positive associations between serum PON3 and β-2-microglobulin, CCL2 and high-sensitivity C-reactive protein in CAD patients, but not in PAD. We did not find any significant differences in PON3 gene promoter polymorphisms and their haplotypes between patients and controls, indicating that associations were not genetically determined. Conclusion In both atherosclerotic phenotypes, serum PON3 concentration was increased, but this was associated with decreased insulin sensitivity in PAD and with inflammation in CAD.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>22153698</pmid><doi>10.1016/j.atherosclerosis.2011.11.021</doi><tpages>7</tpages></addata></record>
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subjects Aged
Aged, 80 and over
Antioxidants
Aryldialkylphosphatase - blood
Aryldialkylphosphatase - genetics
Atherosclerosis
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Biomarkers - blood
Blood and lymphatic vessels
blood serum
C-reactive protein
Cardiology. Vascular system
Cardiovascular
Case-Control Studies
coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - enzymology
Coronary Artery Disease - genetics
Coronary Artery Disease - immunology
Coronary heart disease
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Female
genes
Haplotypes
Heart
Humans
inflammation
Inflammation - blood
Inflammation - enzymology
Inflammation - physiopathology
Inflammation Mediators - blood
insulin
Insulin Resistance
Linkage Disequilibrium
Lipoproteins
Male
Medical sciences
Middle Aged
Myocardial infarction
Paraoxonases
patients
Peripheral Arterial Disease - blood
Peripheral Arterial Disease - enzymology
Peripheral Arterial Disease - genetics
Peripheral Arterial Disease - physiopathology
Peripheral vascular disease
Phenotype
Pilot Projects
polyclonal antibodies
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Spain
Up-Regulation
volunteers
title Serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease
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