Effects of inherited thrombophilia in women with recurrent pregnancy loss

To evaluate the prevalence and effects of inherited thrombophilia caused by factor V Leiden, prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T mutations in women with recurrent pregnancy loss. A study group of 97 women with recurrent miscarriages and a control group of 71 hea...

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Bibliographic Details
Published in:Clinical and experimental obstetrics & gynecology 2011, Vol.38 (4), p.347-350
Main Authors: Habibovic, Z, Zeybek, B, Sanhal, C, Eroglu, Z, Karaca, E, Ulukus, M
Format: Article
Language:English
Subjects:
Abortion, Habitual
Adult
Case-Control Studies
Factor V - genetics
Female
Humans
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Mutation
Pregnancy
Prothrombin - genetics
Thrombophilia - genetics
Young Adult
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Summary:To evaluate the prevalence and effects of inherited thrombophilia caused by factor V Leiden, prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T mutations in women with recurrent pregnancy loss. A study group of 97 women with recurrent miscarriages and a control group of 71 healthy pregnant women were included in the study. Genotype analyses for factor V Leiden, prothrombin G20210A and MTHFR C677T polymorphisms were performed by real-time polymerase chain reaction (RT-PCR). The frequency of factor V Leiden, prothrombin G20210A and MTHFR C677T mutations were similar in both the study and control group. There were eight patients (8.2%) who had more than one gene mutation in the study group and one patient in the control group (1.4%). This difference was not statistically significant. Study group patients (n = 97) were compared in terms of the number of miscarriages and the abortion week, in addition to being a carrier of factor V Leiden and MTHFR C677T gene mutations. No statistically significant correlation was found between being a factor V Leiden and MTHFR C677T mutation carrier with either the number of miscarriages or the abortion week. Factor V Leiden, prothrombin G20210A and MTHFR C677T gene mutations are not individually related with recurrent pregnancy loss. However, combined gene mutation status may be associated with recurrent miscarriages.
ISSN:0390-6663