Dentine as a bioactive extracellular matrix

Abstract As a mineralised connective tissue, dentine is well adapted to its functional role as a major structural component of the tooth. Although similar in composition to bone, dentine matrix is not remodelled physiologically and traditionally, has been regarded as a rather inert tissue. Neverthel...

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Bibliographic Details
Published in:Archives of oral biology 2012-02, Vol.57 (2), p.109-121
Main Authors: Smith, A.J, Scheven, B.A, Takahashi, Y, Ferracane, J.L, Shelton, R.M, Cooper, P.R
Format: Article
Language:English
Subjects:
Advanced Basic Science
Bioactive
Cell Communication
Cytokines - physiology
Dental Pulp - physiology
Dentin - physiology
Dentine
Dentistry
Extracellular matrix
Extracellular Matrix - physiology
Humans
Inflammation
Intercellular Signaling Peptides and Proteins - physiology
Neuropeptides - physiology
Odontoblasts - physiology
Regeneration
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Summary:Abstract As a mineralised connective tissue, dentine is well adapted to its functional role as a major structural component of the tooth. Although similar in composition to bone, dentine matrix is not remodelled physiologically and traditionally, has been regarded as a rather inert tissue. Nevertheless, dentine–pulp demonstrates strong regenerative potential which allows it to respond to disease and traumatic injury. Such responses are strongly influenced by cell–matrix interactions and modified by disease processes, including infection and inflammation. The identification of many bioactive molecules bound within dentine matrix has allowed their potential involvement in regenerative and other tissue responses to be better understood and new opportunities to be recognised for novel clinical therapies.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2011.07.008