Synthesis and immobilization of micro-scale drug particles in presence of β-cyclodextrins

• Published in: Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2012-04, Vol.92, p.213-222
• Main Authors: Meng, Xiangxin, Yang, Dachuan, Keyvan, Golshid, Michniak-Kohn, Bozena, Mitra, Somenath
• Format: Article
• Language: English
• Subjects: 2-Hydroxypropyl-beta-cyclodextrin; Anti-solvent; beta-cyclodextrin; beta-Cyclodextrins - chemistry; Biomaterials; Chemical Precipitation; Chemistry, Pharmaceutical - methods; colloids; Cyclodextrin; Cyclodextrins; Drug delivery; Drug delivery systems; Drugs; Griseofulvin; Griseofulvin - chemical synthesis; Griseofulvin - chemistry; Hydrophobic drugs; Immobilization; Light; Microchemistry - methods; Models, Chemical; Particle Size; Polymer film; Polymeric films; polymers; Polymers - chemistry; Rest; Scattering, Radiation; Solutions; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Surface-Active Agents - chemistry; Suspensions; Synthesis; Time Factors
• ISSN: 0927-7765; 1873-4367
• DOI: 10.1016/j.colsurfb.2011.11.043

[Display omitted] ► Anti-solvent synthesis of micro drug particle and subsequent film formation are presented. ► β-cyclodextrins were capable of inhibiting particle growth and stabilize the drug particles. ► Hydroxypropyl-β-cyclodextrin was found to be most effective in reducing the particle size. ► The drug release showed improvement in release rate due to drug/cyclodextrin interactions. The anti-solvent synthesis in presence of cyclodextrins (CDs) of the drug Griseofulvin (GF) is presented. This was followed by immobilization into cellulosic polymer films suitable for drug delivery. The results show that 72% of the GF precipitated in presence of CD, while the rest led to the formation of a water soluble GF/CD complex. The cyclodextrins were effective in inhibiting particle growth and stabilizing the drug suspensions. Among the CDs tested here, hydroxypropyl-β-cyclodextrin (HPBCD) was found to be most effective in reducing the particle size. The release profiles from the cyclodextrin stabilized GF particles showed improvement in release rate, which indicated effective drug/cyclodextrin interactions.