Increased plasma levels of IL-21 and IL-23 in spondyloarthritis are not associated with clinical and MRI findings

We have investigated the role of the Th17-related cytokines interleukin-17A (IL-17A), IL-21, and IL-23 in spondyloarthritis (SpA) by examining their association with disease activity and magnetic resonance imaging (MRI) findings in patients with SpA ( n  = 80). Furthermore, to investigate the cellul...

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Published in:Rheumatology international 2012-02, Vol.32 (2), p.387-393
Main Authors: Andersen, Thomas, Rasmussen, Tue Kruse, Hvid, Malene, Holm, Christian Kanstrup, Madsen, Karen Jong-Nyo Berenth, Jurik, Anne Grethe, Hokland, Marianne, Stengaard-Pedersen, Kristian, Schiøttz-Christensen, Berit, Deleuran, Bent
Format: Article
Language:English
Subjects:
Adult
Female
Humans
Interleukin-17 - biosynthesis
Interleukin-17 - blood
Interleukin-23 - blood
Interleukins - biosynthesis
Interleukins - blood
Magnetic Resonance Imaging - methods
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Rheumatology
Spondylitis, Ankylosing - blood
Spondylitis, Ankylosing - immunology
Spondylitis, Ankylosing - pathology
Up-Regulation - immunology
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Summary:We have investigated the role of the Th17-related cytokines interleukin-17A (IL-17A), IL-21, and IL-23 in spondyloarthritis (SpA) by examining their association with disease activity and magnetic resonance imaging (MRI) findings in patients with SpA ( n  = 80). Furthermore, to investigate the cellular origins of the cytokines, paired mononuclear cells from blood and synovial fluid were examined for the expression of IL-17A, IL-21, and IL-23R using multicolor flow cytometry. Both IL-21 and IL-23 levels were increased in plasma from SpA patients compared with healthy volunteers ( P  
ISSN:0172-8172
1437-160X
DOI:10.1007/s00296-010-1655-3