Prognostic Impact of Postoperative Serum CA 19-9 Levels in Patients with Resectable Pancreatic Cancer

Background Perioperative serum carbohydrate antigen 19-9 (CA 19-9) level has been reported to be a useful prognostic marker in pancreatic cancer. The object of this study was to investigate the predictive factors for survival, including preoperative and postoperative serum CA 19-9 levels in patients...

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Bibliographic Details
Published in:Annals of surgical oncology 2012-02, Vol.19 (2), p.636-641
Main Authors: Hata, Shojiro, Sakamoto, Yoshihiro, Yamamoto, Yusuke, Nara, Satoshi, Esaki, Minoru, Shimada, Kazuaki, Kosuge, Tomoo
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - blood
CA-19-9 Antigen - blood
Carcinoma, Pancreatic Ductal - blood
Carcinoma, Pancreatic Ductal - mortality
Carcinoma, Pancreatic Ductal - surgery
Female
Follow-Up Studies
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local - blood
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - surgery
Neoplasm Staging
Oncology
Pancreatic cancer
Pancreatic Neoplasms - blood
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - surgery
Pancreatic Tumors
Postoperative Care
Preoperative Care
Prognosis
Prospective Studies
Surgery
Surgical Oncology
Survival Rate
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Summary:Background Perioperative serum carbohydrate antigen 19-9 (CA 19-9) level has been reported to be a useful prognostic marker in pancreatic cancer. The object of this study was to investigate the predictive factors for survival, including preoperative and postoperative serum CA 19-9 levels in patients with pancreatic cancer. Methods Between 2003 and 2009, a total of 269 patients with pancreatic invasive ductal carcinoma underwent macroscopically curative resection, and pre- and postoperative (within 3 months after surgery) serum CA 19-9 levels were evaluated in all of them. The prognostic significance of clinicopathologic factors was evaluated by univariate and multivariate analyses. Results Preoperative serum CA 19-9 levels were higher than normal (>37 U/ml, 38–4600 U/ml) in 218 of 269 patients. Of these, after surgery, serum CA 19-9 level returned to within a normal range in 136 patients (62%), whereas 82 patients (38%) remained in the higher-than-normal range. In univariate and multivariate analyses, node metastasis ( P  37 U/ml) ( P  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-011-2020-9