Release of doxycycline through cellulose acetate symmetric and asymmetric membranes produced from recycled agroindustrial residue: Sugarcane bagasse

• Published in: Industrial crops and products 2011-05, Vol.33 (3), p.566-571
• Main Authors: Rodrigues Filho, Guimes, Ribeiro, Sabrina Dias, Meireles, Carla da Silva, da Silva, Leandro Gustavo, Ruggiero, Reinaldo, Ferreira, Moacir Fernandes, Cerqueira, Daniel Alves, de Assunção, Rosana Maria Nascimento, Zeni, Mara, Polleto, Patricia
• Format: Article
• Language: English
• Subjects: Cellulose; Cellulose triacetate; Controlled-release; Doxycycline; Sugarcane bagasse; Symmetric and asymmetric membranes
• ISSN: 0926-6690; 1872-633X
• DOI: 10.1016/j.indcrop.2010.10.037

▶ Matrices of cellulose from sugar cane bagasse were studied for doxycycline release. ▶ Membranes asymmetric and symmetric were utilized. ▶ The drug release for asymmetric membranes was 80% in 100 min. ▶ While for symmetric membranes the result was 14% at the same time. Cellulose acetate is one of the components employed in drug controlled-release systems in the form of membranes. The aim of this study was to examine the controlled-release of doxycycline employing cellulose acetate symmetric and asymmetric membranes as matrices. The cellulose triacetate was produced from sugarcane bagasse through a homogeneous acetylation reaction, using acetic acid as the solvent, acetic anhydride as the acetylating agent and sulfuric acid as the catalyst. The viscosity average molecular weight of the cellulose acetate produced was 39,000 g mol −1. The symmetric membranes were produced using a system solvent of dichloromethane/ethanol (9:1, v/v) and the asymmetric membranes were produced from the same solvent system and 10% of water. For the formulation of both, 5% of doxycycline was used. The membranes were characterized by thermal analysis (DSC and TGA) and scanning electron microscopy SEM. The release of doxycycline through cellulose triacetate matrices was examined using spectrophotometric analysis in the ultraviolet–visible region, at 275 nm. The results revealed that asymmetric membranes release 80% of the drug in 100 min, while symmetric membranes release 14% of the drug during the same time interval.