New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis

The emergence of vancomycin-resistant bacteria has created an urgent need for new active analogues of vancomycin. We previously reported vancomycin dimers with in vivo antibacterial activity. Here, we provide the first experimental insights into their inhibitory actions in bacterial cell wall synthe...

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Bibliographic Details
Published in:MedChemComm 2011-04, Vol.2 (4), p.278-282
Main Authors: Yoshida, Osamu, Nakamura, Jun, Yamashiro, Hidenori, Miura, Kenji, Hayashi, Sayaka, Umetsu, Kosei, Xu, Shu, Maki, Hideki, Arimoto, Hirokazu
Format: Article
Language:English
Subjects:
Antibacterial activity
Bacteria
Cell walls
Vancomycin
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Summary:The emergence of vancomycin-resistant bacteria has created an urgent need for new active analogues of vancomycin. We previously reported vancomycin dimers with in vivo antibacterial activity. Here, we provide the first experimental insights into their inhibitory actions in bacterial cell wall synthesis.
ISSN:2040-2503
2040-2511
DOI:10.1039/c0md00230e