New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis

The emergence of vancomycin-resistant bacteria has created an urgent need for new active analogues of vancomycin. We previously reported vancomycin dimers with in vivo antibacterial activity. Here, we provide the first experimental insights into their inhibitory actions in bacterial cell wall synthe...

Full description

Saved in:
Bibliographic Details
Published in:MedChemComm 2011-04, Vol.2 (4), p.278-282
Main Authors: Yoshida, Osamu, Nakamura, Jun, Yamashiro, Hidenori, Miura, Kenji, Hayashi, Sayaka, Umetsu, Kosei, Xu, Shu, Maki, Hideki, Arimoto, Hirokazu
Format: Article
Language:English
Subjects:
Antibacterial activity
Bacteria
Cell walls
Vancomycin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c336t-e1daff98e494193eace14ef664f5c798a8f55f9bcb48995be42f3bf59a1427ca3
cites cdi_FETCH-LOGICAL-c336t-e1daff98e494193eace14ef664f5c798a8f55f9bcb48995be42f3bf59a1427ca3
container_end_page 282
container_issue 4
container_start_page 278
container_title MedChemComm
container_volume 2
creator Yoshida, Osamu
Nakamura, Jun
Yamashiro, Hidenori
Miura, Kenji
Hayashi, Sayaka
Umetsu, Kosei
Xu, Shu
Maki, Hideki
Arimoto, Hirokazu
description The emergence of vancomycin-resistant bacteria has created an urgent need for new active analogues of vancomycin. We previously reported vancomycin dimers with in vivo antibacterial activity. Here, we provide the first experimental insights into their inhibitory actions in bacterial cell wall synthesis.
doi_str_mv 10.1039/c0md00230e
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_918045621</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>918045621</sourcerecordid><originalsourceid>FETCH-LOGICAL-c336t-e1daff98e494193eace14ef664f5c798a8f55f9bcb48995be42f3bf59a1427ca3</originalsourceid><addsrcrecordid>eNqFkM1LAzEQxYMoWGov_gW5CcLq5GubHKX4BUUvevC0ZLMTG9nd1M3W0v_elIoencO8B_PjMTxCzhlcMRDm2kHXAHABeEQmHCQUXDF2_OtBnJJZSh-QR3CtjZyQtyfc0tCn8L4as46RjiukXWyQRk-tG0Ps9-7L9i52Oxd62oQOh5RhWuc7DsG21GHb0q3NK-36nJBCOiMn3rYJZz86Ja93ty-Lh2L5fP-4uFkWTohyLJA11nujURrJjEDrkEn0ZSm9cnOjrfZKeVO7WmpjVI2Se1F7ZSyTfO6smJKLQ-56iJ8bTGPVhbT_x_YYN6kyTINUJWf_kyClLsGoTF4eSDfElAb01XoInR12FYNq33X117X4Brq_clE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>904486095</pqid></control><display><type>article</type><title>New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis</title><source>Royal Society of Chemistry</source><creator>Yoshida, Osamu ; Nakamura, Jun ; Yamashiro, Hidenori ; Miura, Kenji ; Hayashi, Sayaka ; Umetsu, Kosei ; Xu, Shu ; Maki, Hideki ; Arimoto, Hirokazu</creator><creatorcontrib>Yoshida, Osamu ; Nakamura, Jun ; Yamashiro, Hidenori ; Miura, Kenji ; Hayashi, Sayaka ; Umetsu, Kosei ; Xu, Shu ; Maki, Hideki ; Arimoto, Hirokazu</creatorcontrib><description>The emergence of vancomycin-resistant bacteria has created an urgent need for new active analogues of vancomycin. We previously reported vancomycin dimers with in vivo antibacterial activity. Here, we provide the first experimental insights into their inhibitory actions in bacterial cell wall synthesis.</description><identifier>ISSN: 2040-2503</identifier><identifier>EISSN: 2040-2511</identifier><identifier>DOI: 10.1039/c0md00230e</identifier><language>eng</language><subject>Antibacterial activity ; Bacteria ; Cell walls ; Vancomycin</subject><ispartof>MedChemComm, 2011-04, Vol.2 (4), p.278-282</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c336t-e1daff98e494193eace14ef664f5c798a8f55f9bcb48995be42f3bf59a1427ca3</citedby><cites>FETCH-LOGICAL-c336t-e1daff98e494193eace14ef664f5c798a8f55f9bcb48995be42f3bf59a1427ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Yoshida, Osamu</creatorcontrib><creatorcontrib>Nakamura, Jun</creatorcontrib><creatorcontrib>Yamashiro, Hidenori</creatorcontrib><creatorcontrib>Miura, Kenji</creatorcontrib><creatorcontrib>Hayashi, Sayaka</creatorcontrib><creatorcontrib>Umetsu, Kosei</creatorcontrib><creatorcontrib>Xu, Shu</creatorcontrib><creatorcontrib>Maki, Hideki</creatorcontrib><creatorcontrib>Arimoto, Hirokazu</creatorcontrib><title>New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis</title><title>MedChemComm</title><description>The emergence of vancomycin-resistant bacteria has created an urgent need for new active analogues of vancomycin. We previously reported vancomycin dimers with in vivo antibacterial activity. Here, we provide the first experimental insights into their inhibitory actions in bacterial cell wall synthesis.</description><subject>Antibacterial activity</subject><subject>Bacteria</subject><subject>Cell walls</subject><subject>Vancomycin</subject><issn>2040-2503</issn><issn>2040-2511</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkM1LAzEQxYMoWGov_gW5CcLq5GubHKX4BUUvevC0ZLMTG9nd1M3W0v_elIoencO8B_PjMTxCzhlcMRDm2kHXAHABeEQmHCQUXDF2_OtBnJJZSh-QR3CtjZyQtyfc0tCn8L4as46RjiukXWyQRk-tG0Ps9-7L9i52Oxd62oQOh5RhWuc7DsG21GHb0q3NK-36nJBCOiMn3rYJZz86Ja93ty-Lh2L5fP-4uFkWTohyLJA11nujURrJjEDrkEn0ZSm9cnOjrfZKeVO7WmpjVI2Se1F7ZSyTfO6smJKLQ-56iJ8bTGPVhbT_x_YYN6kyTINUJWf_kyClLsGoTF4eSDfElAb01XoInR12FYNq33X117X4Brq_clE</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Yoshida, Osamu</creator><creator>Nakamura, Jun</creator><creator>Yamashiro, Hidenori</creator><creator>Miura, Kenji</creator><creator>Hayashi, Sayaka</creator><creator>Umetsu, Kosei</creator><creator>Xu, Shu</creator><creator>Maki, Hideki</creator><creator>Arimoto, Hirokazu</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20110401</creationdate><title>New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis</title><author>Yoshida, Osamu ; Nakamura, Jun ; Yamashiro, Hidenori ; Miura, Kenji ; Hayashi, Sayaka ; Umetsu, Kosei ; Xu, Shu ; Maki, Hideki ; Arimoto, Hirokazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c336t-e1daff98e494193eace14ef664f5c798a8f55f9bcb48995be42f3bf59a1427ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Antibacterial activity</topic><topic>Bacteria</topic><topic>Cell walls</topic><topic>Vancomycin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoshida, Osamu</creatorcontrib><creatorcontrib>Nakamura, Jun</creatorcontrib><creatorcontrib>Yamashiro, Hidenori</creatorcontrib><creatorcontrib>Miura, Kenji</creatorcontrib><creatorcontrib>Hayashi, Sayaka</creatorcontrib><creatorcontrib>Umetsu, Kosei</creatorcontrib><creatorcontrib>Xu, Shu</creatorcontrib><creatorcontrib>Maki, Hideki</creatorcontrib><creatorcontrib>Arimoto, Hirokazu</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>MedChemComm</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoshida, Osamu</au><au>Nakamura, Jun</au><au>Yamashiro, Hidenori</au><au>Miura, Kenji</au><au>Hayashi, Sayaka</au><au>Umetsu, Kosei</au><au>Xu, Shu</au><au>Maki, Hideki</au><au>Arimoto, Hirokazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis</atitle><jtitle>MedChemComm</jtitle><date>2011-04-01</date><risdate>2011</risdate><volume>2</volume><issue>4</issue><spage>278</spage><epage>282</epage><pages>278-282</pages><issn>2040-2503</issn><eissn>2040-2511</eissn><abstract>The emergence of vancomycin-resistant bacteria has created an urgent need for new active analogues of vancomycin. We previously reported vancomycin dimers with in vivo antibacterial activity. Here, we provide the first experimental insights into their inhibitory actions in bacterial cell wall synthesis.</abstract><doi>10.1039/c0md00230e</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 2040-2503
ispartof MedChemComm, 2011-04, Vol.2 (4), p.278-282
issn 2040-2503
2040-2511
language eng
recordid cdi_proquest_miscellaneous_918045621
source Royal Society of Chemistry
subjects Antibacterial activity
Bacteria
Cell walls
Vancomycin
title New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T10%3A05%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%20insight%20into%20the%20mode%20of%20action%20of%20vancomycin%20dimers%20in%20bacterial%20cell%20wall%20synthesis&rft.jtitle=MedChemComm&rft.au=Yoshida,%20Osamu&rft.date=2011-04-01&rft.volume=2&rft.issue=4&rft.spage=278&rft.epage=282&rft.pages=278-282&rft.issn=2040-2503&rft.eissn=2040-2511&rft_id=info:doi/10.1039/c0md00230e&rft_dat=%3Cproquest_cross%3E918045621%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c336t-e1daff98e494193eace14ef664f5c798a8f55f9bcb48995be42f3bf59a1427ca3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=904486095&rft_id=info:pmid/&rfr_iscdi=true