Activity in vitro of hydrogen peroxide vapour against Clostridium difficile spores

Summary Clostridium difficile spores are shed in high numbers by infected patients and are resistant to desiccation and some disinfectants. We explored the in vitro activity of hydrogen peroxide vapour (HPV) against several strains of C. difficile spores using a spore-carrier test. Spores were dried...

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Bibliographic Details
Published in:The Journal of hospital infection 2012-01, Vol.80 (1), p.85-87
Main Authors: Barbut, F, Yezli, S, Otter, J.A
Format: Article
Language:English
Subjects:
Aerosols
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Clostridium difficile
Clostridium difficile - drug effects
Decontamination
Disinfectants - pharmacology
Disinfection
Epidemiology. Vaccinations
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Human bacterial diseases
Human papillomavirus
Humans
Hydrogen Peroxide - pharmacology
Hydrogen peroxide vapour
Infectious Disease
Infectious diseases
Medical sciences
Microbial Viability - drug effects
Other diseases. Semiology
Spore-carrier
Spores
Spores - drug effects
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:Summary Clostridium difficile spores are shed in high numbers by infected patients and are resistant to desiccation and some disinfectants. We explored the in vitro activity of hydrogen peroxide vapour (HPV) against several strains of C. difficile spores using a spore-carrier test. Spores were dried on polyvinyl chloride or laminate carriers at mean concentrations of 4.7–6.9 log10 spores/carrier, which were then decontaminated using HPV. C. difficile was completely eradicated from the exposed carriers regardless of the C. difficile strain or surface used. HPV can be considered for the eradication of C. difficile spores from the hospital environment.
ISSN:0195-6701
1532-2939
DOI:10.1016/j.jhin.2011.10.005