Mesoporous silica nanotubes coated with multilayered polyelectrolytes for pH-controlled drug release

Two kinds of inorganic/organic hybrid composites based on mesoporous silica nanotubes (MSNTs) and pH-responsive polyelectrolytes have been developed as pH-controlled drug delivery systems via the layer by layer self-assembly technique. One system was based on alternatively loading poly(allylamine hy...

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Bibliographic Details
Published in:Acta biomaterialia 2010-08, Vol.6 (8), p.3092-3100
Main Authors: Yang, Yun-Jie, Tao, Xia, Hou, Qian, Ma, Yi, Chen, Xuan-Li, Chen, Jian-Feng
Format: Article
Language:English
Subjects:
Adsorption - drug effects
Cell Line, Tumor
Coated Materials, Biocompatible - pharmacology
Controlled release
Delayed-Action Preparations - pharmacology
Doxorubicin
Doxorubicin - pharmacology
Electrolytes - chemistry
Fluorescein - pharmacology
Humans
Hydrogen-Ion Concentration - drug effects
Mesoporous silica nanotubes
Microscopy, Confocal
Nanotubes - chemistry
Nanotubes - ultrastructure
Nitrogen
pH-responsive
Polyelectrolytes
Porosity - drug effects
Silicon Dioxide - chemistry
Spectroscopy, Fourier Transform Infrared
Temperature
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Summary:Two kinds of inorganic/organic hybrid composites based on mesoporous silica nanotubes (MSNTs) and pH-responsive polyelectrolytes have been developed as pH-controlled drug delivery systems via the layer by layer self-assembly technique. One system was based on alternatively loading poly(allylamine hydrochloride) and sodium poly(styrene sulfonate) onto as-prepared MSNTs to load and release the positively charged drug doxorubicin. The other system was synthesized by alternately coating sodium alginate and chitosan onto amine-functionalized MSNTs, which were used as vehicles for the loading and release of the negatively charged model drug sodium fluorescein. Controlled release of the drug molecules from these delivery systems was achieved by changing the pH value of the release medium. The results of in vitro cell cytotoxicity assays indicated that the cell killing efficacy of the loaded doxorubicin against human fibrosarcoma (HT-1080) and human breast adenocarcinoma (MCF-7) cells was pH dependent. Thus, these hybrid composites could be potentially applicable as pH-controlled drug delivery systems.
ISSN:1742-7061
1878-7568
DOI:10.1016/j.actbio.2010.02.042