Structure and antibacterial activity of the silver(I) complex of 2-aminophenoxazine-3-one

The crystal structure and antibacterial activity of the first metal complex of 2-aminophenoxazine-3-one is reported. We describe the silver(i) complex of this important biological molecule and show that the binding mode is through the phenoxazine ring nitrogen. A new synthetic route to 2-aminophenox...

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Bibliographic Details
Published in:Metallomics 2010-08, Vol.2 (8), p.530-534
Main Authors: Pandurangan, Komala, Gallagher, Shane, Morgan, Grace G, Müller-Bunz, Helge, Paradisi, Francesca
Format: Article
Language:English
Subjects:
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Microbial Sensitivity Tests
Models, Molecular
Molecular Structure
Oxazines - chemistry
Oxazines - pharmacology
Silver - chemistry
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Summary:The crystal structure and antibacterial activity of the first metal complex of 2-aminophenoxazine-3-one is reported. We describe the silver(i) complex of this important biological molecule and show that the binding mode is through the phenoxazine ring nitrogen. A new synthetic route to 2-aminophenoxazine-3-one is also reported.
ISSN:1756-5901
1756-591X
DOI:10.1039/c003515g