Effect of ketamine on exploratory behaviour in BALB/C and C57BL/6 mice

• Published in: Pharmacology, biochemistry and behavior biochemistry and behavior, 2012-01, Vol.100 (3), p.513-517
• Main Authors: Akillioglu, Kubra, Melik, Emine Babar, Melik, Enver, Boga, Ayper
• Format: Article
• Language: English
• Subjects: Anesthetics, Dissociative - administration & dosage; Anesthetics, Dissociative - pharmacology; Animals; Balb/c; Behavior, Animal - drug effects; Biological and medical sciences; C57BL/6; Dose-Response Relationship, Drug; Elevated plus maze; Excitatory Amino Acid Antagonists - administration & dosage; Excitatory Amino Acid Antagonists - pharmacology; Exploratory Behavior - drug effects; Exploratory locomotion ketamine; Ketamine - administration & dosage; Ketamine - pharmacology; Male; Medical sciences; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Open-field; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Reproducibility of Results; Species Specificity
• ISSN: 0091-3057; 1873-5177
• DOI: 10.1016/j.pbb.2011.10.014

In this study, we evaluated the effect of ketamine on exploratory locomotion behaviours in the Balb/c and C57BL/6 strains of mice, which differ in their locomotion behaviours. Intraperitoneal administration of ketamine at three different doses (1, 5 or 10mg/kg, 0.1ml/10 gr body weight) was performed on adult male Balb/c and C57BL/6 mice. The same volume of saline was applied to the control group. The open-field and elevated plus maze apparatus were used to evaluate exploratory locomotion. In the open-field test, Balb/c mice less spend time in the centre of the field and was decreased locomotor activity compared to C57BL/6 mice (p