Antifungal effects of Ficus sycomorus and Pergularia tomentosa aqueous extracts on some organs in Bufo regularis treated with Aspergillus niger

Abstract The antifungal efficacy of Ficus sycomorus and Pergularia tomentosa plant extracts on Bufo regularis experimentally infected with Aspergillus niger was studied. After an oral administration of the pathogen for 15 days, the blood, kidney and liver were examined. Treatment with A. niger produ...

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Bibliographic Details
Published in:Tissue & cell 2011-12, Vol.43 (6), p.398-404
Main Authors: Bekheet, Souad H.M, Abdel-Motaal, Fatma F, Mahalel, Usama A
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Apocynaceae - chemistry
Aspergillus niger
Aspergillus niger - drug effects
Bufo regularis
Bufonidae
Erythrocyte Count
Ficus
Ficus - chemistry
Hemoglobins - analysis
Hepatocytes - drug effects
Hepatocytes - pathology
Histology
Kidney - drug effects
Kidney - injuries
Kidney - pathology
Leukocytes - drug effects
Leukocytes - pathology
Liver - drug effects
Liver - injuries
Liver - pathology
Plant extracts
Plant Extracts - chemistry
Plant Extracts - pharmacology
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Summary:Abstract The antifungal efficacy of Ficus sycomorus and Pergularia tomentosa plant extracts on Bufo regularis experimentally infected with Aspergillus niger was studied. After an oral administration of the pathogen for 15 days, the blood, kidney and liver were examined. Treatment with A. niger produced a reduction in red blood count cells and hemoglobin content. Also, both livers and kidneys revealed marked destruction and degenerative changes. These changes included congestion of blood vessels, leukocytic infiltration, and cytoplasmic vacuolization of the hepatocytes. As well as complete destruction of the cellular boundaries of the tubular epithelia, inflammatory leukocytes between the intertubular spaces, destruction and necrosis in renal tubule cells and the swollen glomeruli with wide glomerular spaces were seen. Pretreatment with F. sycomorus and P. tomentosa plant extracts 1 h prior the administration of A. niger for two weeks improved blood parameters and protected against hepatic and renal damage as observed from histological examination and reduced spore numbers in culture media on these organs.
ISSN:0040-8166
1532-3072
DOI:10.1016/j.tice.2011.09.002