Synthesis and antifungal evaluation of pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones

Pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones were synthesized and tested for in vitro antifungal activity against pathogenic strains of fungi. Many of these tested compounds exhibited potent antifungal activity. Pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]in...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2012-01, Vol.22 (1), p.497-499
Main Authors: Ryu, Chung-Kyu, Yoon, Joo Hee, Song, Ae Li, Im, Hyun Ah, Kim, Ji Young, Kim, Aram
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal
Antifungal agents
Antifungal Agents - pharmacology
antifungal properties
Antimicrobial compounds
Aspergillus flavus - metabolism
Aspergillus niger - metabolism
Benzo[f]pyrido[1,2-a]indole-6,11-dione
Biological and medical sciences
Candida albicans - metabolism
Carbolines - chemical synthesis
Carbolines - pharmacology
chemistry
Chemistry, Pharmaceutical - methods
Drug Design
Fungi
Fungi - drug effects
Indoles - chemistry
Medical sciences
Microbial Sensitivity Tests
Models, Chemical
Pharmacology. Drug treatments
Pyrido[1,2-a]indole-1,4-dione
Saccharomyces cerevisiae - metabolism
Substitution effects
Time Factors
virulent strains
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Summary:Pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones were synthesized and tested for in vitro antifungal activity against pathogenic strains of fungi. Many of these tested compounds exhibited potent antifungal activity. Pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones would be potent antifungal agents.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2011.10.092