Microbial dormancy in batch cultures as a function of substrate-dependent mortality

We present models and computational studies of dormancy in batch cultures to try to understand the relationship between reculturing time and death penalty for low substrate and the relative advantage of fast versus slow reawakening on the part of the bacteria. We find that the advantage goes to the...

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Bibliographic Details
Published in:Journal of theoretical biology 2012-01, Vol.293 (21), p.34-40
Main Author: Ayati, Bruce P.
Format: Article
Language:English
Subjects:
Bacteria
Bacteria - growth & development
Batch Cell Culture Techniques
Cell Division
Culture Media
death
Dormancy
Models, Biological
mortality
Physiological structure
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Summary:We present models and computational studies of dormancy in batch cultures to try to understand the relationship between reculturing time and death penalty for low substrate and the relative advantage of fast versus slow reawakening on the part of the bacteria. We find that the advantage goes to the faster waker for shorter reculturing times and lower mortality under low substrate, and moves to the slower waker as reculturing times and death penalty increase. The advantage returns again to the fast waker for very high death penalties. We use an explicit, continuous structure variable to represent dormancy so as to allow for flexibility in substrate usage on the part of dormant cells, and for a more mechanistic representation of the reawakening process. ► We study the relative advantage of fast versus slow reawakening in bacteria. ► The faster waker wins for shorter reculturing times and lower mortality. ► The slow waker wins as reculturing times and death penalty increase.
ISSN:0022-5193
1095-8541
DOI:10.1016/j.jtbi.2011.10.003