Time for change? An economic evaluation of integrated cervical screening and HPV immunization programs in Canada

Highlights ► We conduct a cost utility analysis of HPV catch-up immunization and cervical screening strategies. ► The analysis uses a dynamic model that captures herd immunity and vaccine cross-protection. ► Adding catch-up immunization to an existing program in pre-adolescent females is cost-effect...

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Bibliographic Details
Published in:Vaccine 2012-01, Vol.30 (2), p.425-435
Main Authors: Tully, Stephen P, Anonychuk, Andrea M, Maria Sanchez, Diana, Galvani, Alison P, Bauch, Chris T
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Age Factors
Aged
Aged, 80 and over
Allergy and Immunology
Canada
Catch-up immunization
Cervical cancer
Cervical screening
Cost-Benefit Analysis
Cost-utility analysis
Costs
Cross Protection
Dynamic model
Early Detection of Cancer - economics
Early Detection of Cancer - methods
Female
Herd immunity
Human papillomavirus
Human papillomavirus vaccine
Humans
Immunity, Herd
Immunization
Immunization Programs
Infections
Male
Males
Mathematical models
Medical screening
Middle Aged
Papillomavirus Infections - diagnosis
Papillomavirus Vaccines - administration & dosage
Papillomavirus Vaccines - economics
Population
Uterine Cervical Neoplasms - immunology
Uterine Cervical Neoplasms - prevention & control
Vaccines
Womens health
Young Adult
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Summary:Highlights ► We conduct a cost utility analysis of HPV catch-up immunization and cervical screening strategies. ► The analysis uses a dynamic model that captures herd immunity and vaccine cross-protection. ► Adding catch-up immunization to an existing program in pre-adolescent females is cost-effective. ► Combining catch-up immunization with a delay in the age of initial screening is cost-saving.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.10.067