The cationic lipid, diC14 amidine, extends the adjuvant properties of aluminum salts through a TLR-4- and caspase-1-independent mechanism

Highlights ► We design a novel adjuvant system based on aluminum salts. ► Cationic lipid diC14 amidine improves innate detection of alum. ► Mixed preparation outperforms sequential addition of both immunomodulators. ► Processing of alum-adsorbed antigen benefits from coupling with diC14 amidine. ► d...

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Bibliographic Details
Published in:Vaccine 2012-01, Vol.30 (2), p.414-424
Main Authors: Wilmar, Arnaud, Lonez, Caroline, Vermeersch, Marjorie, Andrianne, Mathieu, Pérez-Morga, David, Ruysschaert, Jean-Marie, Vandenbranden, Michel, Leo, Oberdan, Temmerman, Stéphane T
Format: Article
Language:English
Subjects:
Adjuvant
Adjuvants, Immunologic - administration & dosage
agonists
Allergy and Immunology
Alum
Alum Compounds - administration & dosage
Aluminum
Amidines - administration & dosage
Animals
Antigen processing
antigen-presenting cells
antigens
Caspase 1 - immunology
caspase-1
Cationic agent
Cell-mediated immunity
Cells, Cultured
coculture
Cytotoxicity
Experiments
Female
humans
Humoral immunity
immune response
Immune system
Immunity, Cellular
Immunity, Humoral
immunoglobulins
Innate immunity
interleukin-1beta
Interleukin-1beta - secretion
Lipids
macrophages
Macrophages - immunology
Male
Medical research
Mice
Mice, Inbred C57BL
Models, Animal
Ovalbumin - immunology
pathogens
salts
Standard deviation
T-lymphocytes
Toll-Like Receptor 4 - immunology
vaccination
Vaccine
Vaccines
Vaccines, Subunit - administration & dosage
Vaccines, Subunit - immunology
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Summary:Highlights ► We design a novel adjuvant system based on aluminum salts. ► Cationic lipid diC14 amidine improves innate detection of alum. ► Mixed preparation outperforms sequential addition of both immunomodulators. ► Processing of alum-adsorbed antigen benefits from coupling with diC14 amidine. ► diC14 amidine enhances antigen-specific humoral and cellular immunity induced by alum.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.10.071