Insulin resistance, low-grade inflammation and type 1 diabetes mellitus

• Published in: Acta diabetologica 2012-02, Vol.49 (1), p.33-39
• Main Authors: Llauradó, G., Gallart, L., Tirado, R., Megia, A., Simón, I., Caixàs, A., Giménez-Palop, O., Berlanga, E., Vendrell, J., González-Clemente, J. M.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Blood Glucose - metabolism; Blood Pressure - physiology; C-Reactive Protein - analysis; Cohort Studies; Diabetes; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - epidemiology; Diabetes Mellitus, Type 1 - physiopathology; Female; Humans; Inflammation - complications; Inflammation - epidemiology; Inflammatory diseases; Insulin - blood; Insulin resistance; Insulin Resistance - physiology; Internal Medicine; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Original Article; Young Adult
• ISSN: 0940-5429; 1432-5233
• DOI: 10.1007/s00592-011-0257-1

To assess the relationships between insulin resistance and low-grade inflammation in subjects with type 1 diabetes mellitus (T1DM) who do not have clinical macrovascular complications. A total of 120 subjects diagnosed with T1DM 14 years before were evaluated for the following: (1) sex, age, body mass index, waist-to-hip ratio (WHR), blood pressure, smoking, alcohol intake, insulin dose, HbA1c and lipid profile; (2) microvascular complications; (3) plasma concentrations of soluble fractions of tumour necrosis factor-α receptors type 1 and 2, interleukin-6, adiponectin, leptin and high-sensitivity C-reactive protein (hs-CRP); and (4) insulin resistance (estimation of the glucose disposal rate—eGDR). Those subjects with an eGDR below the median of the same sex group were classified as insulin resistant and the others as insulin sensitive. Insulin-resistant men, compared to the insulin-sensitive, had higher WHR (0.89 ± 0.08 vs. 0.83 ± 0.05; P