Natural Polymorphisms and Resistance-Associated Mutations in the Fusion Protein of Respiratory Syncytial Virus (RSV): Effects on RSV Susceptibility to Palivizumab

Specific mutations in respiratory syncytial virus (RSV) fusion protein can cause palivizumab resistance. We assessed the incidence of sequence polymorphisms and palivizumab resistance in clinical RSV isolates collected from immunoprophylaxisnaive subjects. Polymorphisms were identified at low freque...

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Bibliographic Details
Published in:The Journal of infectious diseases 2012-02, Vol.205 (4), p.635-638
Main Authors: Zhu, Qing, Patel, Nita K., McAuliffe, Josephine M., Zhu, Wei, Wachter, Leslie, McCarthy, Michael P., Suzich, JoAnn A.
Format: Article
Language:English
Subjects:
Amino acids
Antibodies, Monoclonal, Humanized - pharmacology
Antigens, Viral - genetics
Antigens, Viral - immunology
Antiviral Agents - pharmacology
Biological and medical sciences
Child, Preschool
Drug Resistance, Viral
Epitopes - genetics
Fundamental and applied biological sciences. Psychology
Genetic mutation
Human respiratory syncytial virus
Humans
Infant
Infant, Newborn
Infants
Infectious diseases
Inhibitory concentration 50
Medical sciences
Microbiology
Monoclonal antibodies
Mutation, Missense
Palivizumab
Phenotypes
Polymorphism, Genetic
Respiratory syncytial viruses
Respiratory Syncytial Viruses - genetics
Vero cells
Viral Fusion Proteins - genetics
Viral Fusion Proteins - immunology
Viruses
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Description
Summary:Specific mutations in respiratory syncytial virus (RSV) fusion protein can cause palivizumab resistance. We assessed the incidence of sequence polymorphisms and palivizumab resistance in clinical RSV isolates collected from immunoprophylaxisnaive subjects. Polymorphisms were identified at low frequency, and only polymorphic mutations in antigenic site A (
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jir790